Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 5252777..5253402 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS24090 Protein ID WP_085234802.1
Coordinates 5252777..5253157 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS24095 Protein ID WP_085234803.1
Coordinates 5253154..5253402 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS24065 5247937..5248977 - 1041 WP_085234797.1 LLM class F420-dependent oxidoreductase -
G6N66_RS24070 5249035..5250024 + 990 WP_179968313.1 OB-fold nucleic acid binding domain-containing protein -
G6N66_RS24075 5250040..5251104 + 1065 WP_085234799.1 thiolase domain-containing protein -
G6N66_RS24080 5251104..5252291 + 1188 WP_085234800.1 thiolase domain-containing protein -
G6N66_RS24085 5252288..5252689 + 402 WP_085234801.1 nuclear transport factor 2 family protein -
G6N66_RS24090 5252777..5253157 - 381 WP_085234802.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS24095 5253154..5253402 - 249 WP_085234803.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N66_RS24100 5253560..5254084 - 525 WP_085234804.1 gamma carbonic anhydrase family protein -
G6N66_RS24105 5254204..5255373 + 1170 WP_085234805.1 3-ketosteroid-9-alpha-hydroxylase subunit A -
G6N66_RS24110 5255379..5255828 + 450 WP_085234806.1 hypothetical protein -
G6N66_RS24115 5255801..5256397 - 597 WP_085234807.1 TetR/AcrR family transcriptional regulator -
G6N66_RS24120 5256499..5256777 + 279 WP_085234861.1 hypothetical protein -
G6N66_RS24125 5256779..5257924 - 1146 WP_085234808.1 sulfotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-112)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13503.44 Da        Isoelectric Point: 5.9735

>T36367 WP_085234802.1 NZ_AP022613:c5253157-5252777 [Mycobacterium conspicuum]
VRAVLDTSVVIATEVEPLDGELAISAITLAELHFGVLVAHEQKVRSERLRRLLVAQRKFDALPVDDAVAASYGQVAAAVV
DVGRQSRARSMDLLIAATAHAHAARLYTRNAHDFDGLGDLVDVVPV

Download         Length: 381 bp

>T36367 NZ_AP022613:c5253157-5252777 [Mycobacterium conspicuum]
GTGAGAGCGGTTTTAGACACCAGTGTGGTCATTGCGACGGAGGTCGAGCCCCTTGACGGCGAGTTGGCTATCAGCGCAAT
CACATTGGCCGAACTGCACTTCGGGGTTCTGGTGGCGCACGAACAAAAGGTGCGCTCGGAGCGGCTGCGGCGCCTGCTGG
TCGCTCAGCGTAAGTTCGACGCGCTACCTGTAGATGACGCCGTAGCAGCTAGCTACGGCCAGGTGGCGGCTGCCGTCGTT
GACGTGGGACGTCAGTCGCGCGCGCGGTCAATGGACCTGCTTATAGCTGCGACCGCCCACGCTCACGCTGCACGGCTTTA
CACCCGCAACGCCCACGACTTTGACGGCCTCGGCGACCTGGTGGACGTCGTGCCGGTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9140.23 Da        Isoelectric Point: 5.1088

>AT36367 WP_085234803.1 NZ_AP022613:c5253402-5253154 [Mycobacterium conspicuum]
MSTVGLRELRQKASDLVRRAGDGEEITITVAGRPAARLAPPASRTWRRWAEVSELFAGPADPAWNADRESIAQDIRDPWI
EQ

Download         Length: 249 bp

>AT36367 NZ_AP022613:c5253402-5253154 [Mycobacterium conspicuum]
ATGTCGACGGTTGGATTGCGCGAACTTCGCCAGAAAGCCTCCGATCTGGTGCGCCGCGCCGGGGACGGGGAGGAGATCAC
CATCACCGTGGCCGGCCGCCCGGCGGCCCGGCTTGCACCTCCGGCTTCTCGAACCTGGAGGAGGTGGGCCGAGGTGTCCG
AATTGTTCGCCGGGCCCGCGGATCCCGCGTGGAATGCCGACCGTGAGTCGATCGCCCAGGACATACGCGACCCGTGGATA
GAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References