Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 4394727..4395331 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS20020 Protein ID WP_085235349.1
Coordinates 4394727..4395119 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS20025 Protein ID WP_085235360.1
Coordinates 4395116..4395331 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS20005 4390471..4391025 - 555 WP_179968292.1 TIGR00730 family Rossman fold protein -
G6N66_RS20010 4391065..4393158 + 2094 WP_085235351.1 AAA family ATPase -
G6N66_RS20015 4393218..4394717 + 1500 WP_085235350.1 cellulase family glycosylhydrolase -
G6N66_RS20020 4394727..4395119 - 393 WP_085235349.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS20025 4395116..4395331 - 216 WP_085235360.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N66_RS20030 4395486..4395884 - 399 WP_169721542.1 type II toxin-antitoxin system VapC family toxin -
G6N66_RS20035 4395884..4396132 - 249 WP_085235348.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N66_RS20040 4396233..4397297 - 1065 WP_085235347.1 succinyl-diaminopimelate desuccinylase -
G6N66_RS20045 4397334..4398287 + 954 WP_139825442.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-38)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14621.79 Da        Isoelectric Point: 7.4771

>T36365 WP_085235349.1 NZ_AP022613:c4395119-4394727 [Mycobacterium conspicuum]
MTTVLLDSHVVHWWSAEPERLSKAACRAVEAADELAVAGITWFELAWLAEHDRIRLAIPVRSWLQQLAEDVRTVGITPSV
AAAAVSLPSTFPGDPADRLIYATAVEHGWRLVTKDRRMRNHKHPRPVTVW

Download         Length: 393 bp

>T36365 NZ_AP022613:c4395119-4394727 [Mycobacterium conspicuum]
ATGACAACGGTGCTGCTGGACTCCCACGTCGTCCACTGGTGGTCAGCCGAGCCCGAGCGGCTGAGCAAGGCCGCGTGCCG
GGCCGTCGAAGCAGCCGACGAGCTTGCGGTTGCGGGCATCACCTGGTTCGAACTGGCATGGCTTGCCGAACATGACCGCA
TTCGACTCGCGATCCCGGTTCGGTCCTGGCTGCAGCAGCTGGCTGAGGACGTTCGCACCGTTGGGATCACGCCTTCGGTG
GCCGCTGCCGCGGTGTCGCTGCCGTCTACGTTCCCTGGCGATCCGGCCGACCGGTTGATCTATGCCACCGCCGTCGAACA
CGGGTGGCGCCTGGTGACCAAGGACCGACGGATGCGTAACCATAAGCACCCGCGCCCGGTCACCGTTTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7448.56 Da        Isoelectric Point: 5.8021

>AT36365 WP_085235360.1 NZ_AP022613:c4395331-4395116 [Mycobacterium conspicuum]
MTATEVKAKILALLDEVAEGEEIEITKHGRTVARLVSAPGARALKGRLGGVAITAVEEDKLFTTGVSWNAS

Download         Length: 216 bp

>AT36365 NZ_AP022613:c4395331-4395116 [Mycobacterium conspicuum]
ATGACCGCCACCGAGGTTAAGGCGAAAATCCTTGCCTTGCTCGACGAAGTCGCCGAGGGTGAGGAGATCGAAATCACCAA
GCACGGCCGCACCGTGGCCCGGCTTGTCTCGGCGCCTGGCGCCCGCGCCCTCAAGGGCCGGCTGGGCGGGGTCGCGATCA
CCGCCGTGGAGGAGGACAAGCTCTTTACCACCGGAGTGTCCTGGAATGCTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References