Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3660441..3661116 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS16955 Protein ID WP_085231230.1
Coordinates 3660441..3660872 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS16960 Protein ID WP_085231231.1
Coordinates 3660859..3661116 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS16935 3655815..3656450 - 636 WP_085231227.1 class I SAM-dependent methyltransferase -
G6N66_RS16940 3656473..3656607 + 135 Protein_3361 hypothetical protein -
G6N66_RS16945 3656827..3659712 - 2886 WP_085231228.1 DUF4349 domain-containing protein -
G6N66_RS16950 3659687..3660350 - 664 Protein_3363 hypothetical protein -
G6N66_RS16955 3660441..3660872 - 432 WP_085231230.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS16960 3660859..3661116 - 258 WP_085231231.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N66_RS16965 3661604..3662062 + 459 WP_085231232.1 hypothetical protein -
G6N66_RS16970 3662065..3662928 - 864 WP_085231233.1 L,D-transpeptidase -
G6N66_RS16975 3663155..3664507 + 1353 WP_085231234.1 MHS family MFS transporter -
G6N66_RS16980 3664500..3665882 - 1383 WP_085231235.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-37)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16156.38 Da        Isoelectric Point: 5.9775

>T36363 WP_085231230.1 NZ_AP022613:c3660872-3660441 [Mycobacterium conspicuum]
MLCVDVNVLVYAHRADLPEHSAYRQLLERLANGDEPLGLPDLTLGGFVRVMTNRRIFSEPTNSDEAWLAVNALLEAPAAM
QLRAGQRHWMLFRQLATDIDARGNDVADAYLAAYALENSATWLSADRGFARFHRLRWVHPLDL

Download         Length: 432 bp

>T36363 NZ_AP022613:c3660872-3660441 [Mycobacterium conspicuum]
ATGCTTTGCGTTGATGTCAACGTCCTCGTTTATGCGCACCGCGCCGATCTGCCCGAGCATTCGGCCTACCGACAGCTGCT
GGAACGGCTGGCGAACGGTGATGAGCCTTTAGGTCTGCCGGATCTGACCCTCGGTGGATTCGTCCGCGTGATGACCAATC
GCCGGATCTTCTCCGAACCGACAAATTCAGACGAGGCATGGCTTGCGGTCAATGCGCTGCTCGAAGCGCCTGCGGCCATG
CAACTTCGCGCCGGCCAACGACATTGGATGTTGTTTCGTCAACTCGCGACCGACATCGACGCACGCGGCAACGACGTCGC
GGATGCTTATCTGGCTGCGTACGCGCTTGAGAACAGCGCGACGTGGTTGAGCGCAGACCGCGGCTTCGCACGCTTCCACC
GACTGCGCTGGGTTCATCCACTCGATCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9151.38 Da        Isoelectric Point: 11.0903

>AT36363 WP_085231231.1 NZ_AP022613:c3661116-3660859 [Mycobacterium conspicuum]
MRTTIRIDDELYRQVKAMAARSGRTVAAVLEDAIRRGLSPSERRASGHYAVRPTGRGGLRSGVDLSSRAAIAEAMDEGAP
IDALR

Download         Length: 258 bp

>AT36363 NZ_AP022613:c3661116-3660859 [Mycobacterium conspicuum]
ATGCGCACGACAATCCGCATCGACGACGAGCTCTACCGCCAAGTGAAGGCGATGGCCGCTCGCTCCGGGCGTACCGTCGC
CGCGGTCCTCGAAGACGCGATTCGGCGAGGTCTAAGCCCGTCCGAACGGCGAGCTAGCGGTCATTACGCCGTCCGTCCGA
CGGGGAGGGGAGGGCTTCGTTCCGGCGTAGACCTCTCATCCCGTGCCGCCATCGCTGAGGCGATGGACGAAGGCGCTCCG
ATCGATGCTTTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References