36362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3598246..3598864 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS16655 Protein ID WP_085231179.1
Coordinates 3598246..3598647 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS16660 Protein ID WP_085231180.1
Coordinates 3598634..3598864 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS16630 3594095..3594853 - 759 WP_085231282.1 serine/threonine protein kinase -
G6N66_RS16635 3595091..3595384 + 294 WP_085231175.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N66_RS16640 3595381..3595785 + 405 WP_085231176.1 type II toxin-antitoxin system VapC family toxin -
G6N66_RS16645 3595883..3597142 + 1260 WP_085231177.1 alpha/beta hydrolase -
G6N66_RS16650 3597139..3598170 + 1032 WP_085231178.1 hypothetical protein -
G6N66_RS16655 3598246..3598647 - 402 WP_085231179.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS16660 3598634..3598864 - 231 WP_085231180.1 hypothetical protein Antitoxin
G6N66_RS16665 3598938..3600326 + 1389 WP_085231181.1 FAD-binding oxidoreductase -
G6N66_RS16670 3600545..3601189 - 645 WP_085231182.1 TIGR03085 family protein -
G6N66_RS16675 3601201..3601836 - 636 WP_085231183.1 PAS and ANTAR domain-containing protein -
G6N66_RS16680 3601890..3602369 - 480 WP_085231184.1 hypothetical protein -
G6N66_RS16685 3602423..3603056 + 634 Protein_3310 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14527.68 Da        Isoelectric Point: 5.6046

>T36362 WP_085231179.1 NZ_AP022613:c3598647-3598246 [Mycobacterium conspicuum]
VIVVDASVLAVALGDDGTDGQQARERLADDTLAAPELIDLEVVSVWRRQVAAKQMPARRAESAIADLAVLPLSRSSHQPM
LHRIWELRHAITPYDAAYVALAEALDVVLVTADMRLSRAAGVRCEIEALRTHR

Download         Length: 402 bp

>T36362 NZ_AP022613:c3598647-3598246 [Mycobacterium conspicuum]
GTGATCGTCGTTGACGCGAGCGTGCTGGCCGTTGCGCTGGGCGATGATGGGACAGACGGGCAGCAGGCCCGCGAACGTCT
AGCGGACGACACCTTGGCCGCTCCCGAACTCATCGACCTTGAGGTGGTCTCGGTGTGGCGCCGACAGGTCGCTGCAAAAC
AAATGCCCGCCCGCAGGGCCGAAAGCGCGATTGCAGACCTGGCGGTTTTGCCGTTGAGCCGGTCCTCGCACCAACCAATG
CTGCACCGCATATGGGAACTGCGGCATGCCATCACGCCATACGACGCGGCCTACGTCGCACTGGCCGAGGCCCTGGACGT
TGTGCTGGTCACCGCTGATATGCGCCTGTCGCGGGCTGCAGGCGTTCGTTGCGAGATCGAGGCCTTGAGAACACATCGCT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8722.78 Da        Isoelectric Point: 11.0396

>AT36362 WP_085231180.1 NZ_AP022613:c3598864-3598634 [Mycobacterium conspicuum]
MPSVQIKDVPDDTHRVLRERAARAHQSLQEYLRSRLIADANQPTLDEVFDRVAARRGGRVPFSAAVDQVRADRDRR

Download         Length: 231 bp

>AT36362 NZ_AP022613:c3598864-3598634 [Mycobacterium conspicuum]
ATGCCTAGCGTGCAGATCAAAGACGTACCCGATGACACCCACCGTGTCCTACGGGAGCGGGCCGCGCGCGCGCATCAGTC
CCTGCAGGAATACCTTCGCAGCCGGCTGATCGCCGACGCGAACCAACCAACTCTGGATGAAGTCTTCGACCGCGTCGCGG
CGCGCCGCGGGGGCCGGGTGCCGTTTTCGGCCGCCGTCGATCAGGTTCGCGCAGACCGTGATCGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References