Detailed information of TA system TA036361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3549938..3550566
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N66_RS16450
• Protein ID: WP_085231146.1
• Coordinates: 3549938..3550339 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N66_RS16455
• Protein ID: WP_085231147.1
• Coordinates: 3550336..3550566 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS16420	3546320..3546580	+	261	WP_085231142.1	type II toxin-antitoxin system VapB family antitoxin	-
G6N66_RS16425	3546589..3547017	+	429	WP_085231143.1	type II toxin-antitoxin system VapC family toxin	-
G6N66_RS29030	3547078..3547146	-	69	Protein_3260	VapC toxin family PIN domain ribonuclease	-
G6N66_RS16435	3547166..3547426	-	261	WP_085231144.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
G6N66_RS16440	3547580..3547942	+	363	WP_085231277.1	hypothetical protein	-
G6N66_RS16445	3548053..3549327	+	1275	WP_085231145.1	hypothetical protein	-
G6N66_RS16450	3549938..3550339	-	402	WP_085231146.1	PIN domain-containing protein	Toxin
G6N66_RS16455	3550336..3550566	-	231	WP_085231147.1	antitoxin	Antitoxin
G6N66_RS16460	3550630..3551157	-	528	WP_179968356.1	hypothetical protein	-
G6N66_RS16465	3551808..3552212	-	405	WP_085231279.1	type II toxin-antitoxin system VapC family toxin	-
G6N66_RS16470	3552236..3552472	-	237	WP_179968279.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
G6N66_RS16475	3552582..3553280	+	699	WP_085231149.1	crotonase/enoyl-CoA hydratase family protein	-
G6N66_RS16480	3553286..3553876	+	591	WP_085231150.1	TetR/AcrR family transcriptional regulator	-
G6N66_RS16485	3553886..3554668	-	783	WP_085231151.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14156.91 Da
• Isoelectric Point: 5.7621

>T36361 WP_085231146.1 NZ_AP022613:c3550339-3549938 [Mycobacterium conspicuum]
VTALLDANVLIALVVSEHVHHDAAAEWLSASWTEFATCPITQGRLVRFLVRTGQSATAAREVVAAVRSANGHEFWPDAVS
FADVDVGGVVGHRQITDAYLAQLARSHKGQLATLDSGLAHLHDDVAVLIPTES

Nucleotide

• Length: 402 bp

>T36361 NZ_AP022613:c3550339-3549938 [Mycobacterium conspicuum]
GTGACGGCGCTGCTTGACGCGAACGTGCTCATTGCACTGGTCGTCAGCGAGCATGTGCATCACGACGCCGCCGCGGAATG
GCTATCGGCATCCTGGACAGAATTCGCCACGTGCCCGATCACACAGGGGAGACTTGTTCGGTTCCTGGTCCGGACGGGTC
AGTCCGCGACGGCCGCTCGCGAAGTCGTCGCCGCAGTCCGGAGTGCGAACGGCCACGAGTTCTGGCCTGACGCTGTCTCT
TTCGCCGACGTCGACGTCGGCGGTGTGGTCGGTCACCGACAGATAACGGATGCCTACCTCGCGCAGCTCGCACGCAGCCA
CAAGGGTCAGCTGGCCACTCTTGATAGCGGCTTAGCGCACCTGCACGACGACGTCGCGGTGCTCATCCCCACGGAAAGCT
GA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8181.18 Da
• Isoelectric Point: 4.7483

>AT36361 WP_085231147.1 NZ_AP022613:c3550566-3550336 [Mycobacterium conspicuum]
VRTTIDLPADLHKQALSIARDTHRTLSETVADLMRRGLRAAAGTAEISIDPRTGLPVVSVGTVVTSEDVRSLEDEE

Nucleotide

• Length: 231 bp

>AT36361 NZ_AP022613:c3550566-3550336 [Mycobacterium conspicuum]
GTGCGTACCACCATCGATCTCCCCGCCGACCTGCACAAACAGGCGCTGTCGATCGCGCGGGACACCCACCGGACGCTGAG
CGAAACCGTCGCCGACCTCATGCGTCGCGGCCTGCGTGCCGCCGCCGGCACCGCCGAGATCTCGATAGATCCACGGACGG
GCTTGCCTGTTGTCAGCGTGGGGACGGTCGTGACGTCGGAGGACGTGCGGTCATTGGAGGATGAGGAGTGA