Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3546320..3547017 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS16425 Protein ID WP_085231143.1
Coordinates 3546589..3547017 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS16420 Protein ID WP_085231142.1
Coordinates 3546320..3546580 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS16405 3542212..3543513 + 1302 WP_085231139.1 MCE family protein -
G6N66_RS16410 3543510..3544712 + 1203 WP_085231140.1 MCE family protein -
G6N66_RS16415 3544712..3546277 + 1566 WP_085231141.1 MCE family protein -
G6N66_RS16420 3546320..3546580 + 261 WP_085231142.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N66_RS16425 3546589..3547017 + 429 WP_085231143.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS29030 3547078..3547146 - 69 Protein_3260 VapC toxin family PIN domain ribonuclease -
G6N66_RS16435 3547166..3547426 - 261 WP_085231144.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
G6N66_RS16440 3547580..3547942 + 363 WP_085231277.1 hypothetical protein -
G6N66_RS16445 3548053..3549327 + 1275 WP_085231145.1 hypothetical protein -
G6N66_RS16450 3549938..3550339 - 402 WP_085231146.1 PIN domain-containing protein -
G6N66_RS16455 3550336..3550566 - 231 WP_085231147.1 antitoxin -
G6N66_RS16460 3550630..3551157 - 528 WP_179968356.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15355.56 Da        Isoelectric Point: 6.0741

>T36360 WP_085231143.1 NZ_AP022613:3546589-3547017 [Mycobacterium conspicuum]
MMIDTSAIVALVQDEEPYATQVVAALANARERVMSAPTVAECLIVLTARHGPLARTVFERLRNEISLGVVHFTEEHATAA
QRAFLQYGKGRHPAALNFGDCMTYAAAQLSREPLLAIGNAFAQTDLEFSGVIGYWPAPGRPS

Download         Length: 429 bp

>T36360 NZ_AP022613:3546589-3547017 [Mycobacterium conspicuum]
ATGATGATCGACACAAGCGCCATCGTGGCGCTGGTTCAAGACGAGGAACCTTACGCCACCCAGGTGGTCGCCGCGCTGGC
CAACGCCCGCGAACGGGTCATGTCGGCACCCACGGTGGCCGAATGCTTAATCGTCTTGACCGCCCGTCATGGTCCGTTGG
CGCGCACCGTTTTTGAACGCCTACGCAACGAAATCTCCTTAGGCGTAGTTCATTTCACTGAAGAACATGCCACAGCGGCT
CAACGGGCCTTCTTGCAGTACGGTAAGGGTCGGCACCCCGCGGCTCTGAACTTCGGAGACTGCATGACTTATGCGGCCGC
CCAGCTGAGCCGCGAACCACTGTTAGCCATCGGCAATGCCTTCGCCCAGACCGACCTCGAATTCAGCGGCGTCATCGGCT
ACTGGCCCGCACCGGGCAGGCCCAGCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9818.16 Da        Isoelectric Point: 4.8660

>AT36360 WP_085231142.1 NZ_AP022613:3546320-3546580 [Mycobacterium conspicuum]
MALNIKDPEVDRLANELATRLQTNKTDAIRRALRAQLGLLESRAGDRETQLLDVMRTEIWPLLTDRSPITKREREEILGY
DADTGV

Download         Length: 261 bp

>AT36360 NZ_AP022613:3546320-3546580 [Mycobacterium conspicuum]
ATGGCGCTGAACATCAAAGATCCCGAGGTGGACCGGCTCGCGAACGAACTCGCGACACGGCTTCAAACGAACAAAACCGA
CGCCATTCGCCGAGCCCTTCGTGCCCAGCTTGGACTGTTGGAATCGCGCGCTGGCGACCGCGAAACACAGCTCTTGGACG
TGATGCGCACCGAAATCTGGCCGTTACTCACCGACCGCAGCCCGATCACCAAGCGCGAACGCGAGGAAATCCTTGGCTAT
GACGCCGATACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References