Detailed information of TA system TA036359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 3406044..3406591
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N66_RS15695
• Protein ID: WP_085232476.1
• Coordinates: 3406044..3406226 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N66_RS15700
• Protein ID: WP_085232477.1
• Coordinates: 3406325..3406591 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS15675	3401734..3402345	+	612	WP_085232473.1	heme-copper oxidase subunit III	-
G6N66_RS15680	3402440..3403198	+	759	WP_139825153.1	cytochrome c	-
G6N66_RS15685	3403195..3404376	+	1182	WP_085232487.1	ubiquinol-cytochrome c reductase iron-sulfur subunit	-
G6N66_RS15690	3404373..3406031	+	1659	WP_085232475.1	cytochrome bc complex cytochrome b subunit	-
G6N66_RS15695	3406044..3406226	-	183	WP_085232476.1	hypothetical protein	Toxin
G6N66_RS15700	3406325..3406591	-	267	WP_085232477.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N66_RS15705	3406611..3407252	-	642	WP_085232478.1	DUF2561 family protein	-
G6N66_RS15710	3407252..3408145	-	894	WP_163645857.1	hypothetical protein	-
G6N66_RS15715	3408330..3408749	-	420	WP_085232970.1	cytochrome c oxidase subunit 4	-
G6N66_RS15720	3408758..3409813	-	1056	WP_085232971.1	cytochrome c oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-44)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6364.26 Da
• Isoelectric Point: 5.6555

>T36359 WP_085232476.1 NZ_AP022613:c3406226-3406044 [Mycobacterium conspicuum]
MTRQLLDESGTLQPLRLRSLDAIHLVAAQRAGDALRTVVTYDAGMLSAAADLGIATDSPR

Nucleotide

• Length: 183 bp

>T36359 NZ_AP022613:c3406226-3406044 [Mycobacterium conspicuum]
TTGACCCGACAACTGCTCGACGAGTCCGGCACGCTGCAGCCGTTAAGGCTTCGCAGCCTTGACGCGATTCACCTCGTCGC
CGCACAGCGCGCCGGTGACGCCCTGCGTACCGTCGTCACGTACGACGCTGGAATGCTTTCAGCCGCAGCGGATCTCGGCA
TCGCCACCGACTCGCCGCGCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9726.82 Da
• Isoelectric Point: 4.6677

>AT36359 WP_085232477.1 NZ_AP022613:c3406591-3406325 [Mycobacterium conspicuum]
MKSIGVRELRQNASKYLADVESGESIEITDRGRPVARLVPVSGDPWQDLINAGDVVPASRSLQAGDLRPESYPHSRIEAL
EELRGDER

Nucleotide

• Length: 267 bp

>AT36359 NZ_AP022613:c3406591-3406325 [Mycobacterium conspicuum]
ATGAAGAGCATCGGCGTCCGCGAACTACGTCAAAACGCCAGCAAGTACTTGGCGGATGTCGAGTCGGGGGAGTCGATCGA
GATCACCGACCGGGGTCGACCCGTCGCGCGTCTGGTGCCGGTATCGGGCGACCCGTGGCAAGACCTAATCAATGCTGGAG
ACGTCGTGCCGGCGTCACGTTCATTGCAGGCTGGCGATCTCAGGCCCGAGTCTTACCCGCATAGCCGCATCGAAGCCCTT
GAGGAACTGCGCGGCGACGAACGCTGA