Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3127262..3128263 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N66_RS14575 Protein ID WP_085232825.1
Coordinates 3127262..3127840 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N66_RS14580 Protein ID WP_085232826.1
Coordinates 3127853..3128263 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS14555 3124476..3124709 + 234 WP_085232822.1 hypothetical protein -
G6N66_RS14560 3124706..3125040 + 335 Protein_2890 type II toxin-antitoxin system PemK/MazF family toxin -
G6N66_RS14565 3125465..3126550 + 1086 WP_085232823.1 hydroxyneurosporene methyltransferase -
G6N66_RS14570 3126566..3127183 - 618 WP_139825194.1 TetR family transcriptional regulator -
G6N66_RS14575 3127262..3127840 - 579 WP_085232825.1 zeta toxin family protein Toxin
G6N66_RS14580 3127853..3128263 - 411 WP_085232826.1 hypothetical protein Antitoxin
G6N66_RS14585 3128429..3129259 - 831 WP_085232827.1 DUF1906 domain-containing protein -
G6N66_RS14590 3129615..3129821 + 207 WP_085232828.1 DUF2191 domain-containing protein -
G6N66_RS14595 3129812..3130234 + 423 WP_085232829.1 PIN domain-containing protein -
G6N66_RS14600 3131103..3131690 + 588 WP_085232830.1 hypothetical protein -
G6N66_RS14605 3131675..3132337 + 663 WP_085233006.1 RES family NAD+ phosphorylase -
G6N66_RS14610 3132398..3133006 + 609 WP_085232831.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20922.86 Da        Isoelectric Point: 7.0631

>T36358 WP_085232825.1 NZ_AP022613:c3127840-3127262 [Mycobacterium conspicuum]
MNRLDLVVGPNGAGKSTFVELTLAPLLPGSVFVNADEIARQRWPDDPASHAYEAAAVAADTRSRLIELGRSFIAETVFSH
PSKLELIDAAHAGGYTVVLHVLLIPEELAVQRVRHRASAGGHDVPEDKIRERYQRLWALVAAAITRSDSATVYDNSTLKG
PRIVAQLSSGVIVGCPSWPIWAPEPLRSRWSM

Download         Length: 579 bp

>T36358 NZ_AP022613:c3127840-3127262 [Mycobacterium conspicuum]
ATGAACCGGCTCGATCTCGTCGTCGGACCCAACGGTGCCGGCAAGTCGACATTCGTCGAACTCACGCTGGCTCCGCTCCT
ACCCGGCAGCGTGTTCGTCAACGCCGACGAGATCGCCAGACAACGCTGGCCCGACGACCCGGCATCGCATGCGTACGAGG
CCGCGGCGGTTGCCGCCGACACCCGTTCAAGACTGATCGAACTGGGCCGGTCGTTCATCGCGGAAACCGTGTTCTCCCAC
CCGTCGAAGCTCGAGCTGATCGACGCCGCCCACGCGGGGGGCTACACCGTTGTTCTGCACGTGCTGCTGATCCCCGAAGA
ATTGGCCGTGCAACGCGTCAGGCACCGGGCCAGCGCCGGCGGCCACGATGTGCCCGAGGATAAGATTCGCGAACGCTATC
AACGCCTCTGGGCTCTCGTCGCTGCCGCGATCACCCGATCCGACTCGGCGACCGTCTACGACAACAGCACCCTGAAGGGC
CCCCGCATTGTGGCGCAGCTGAGCTCTGGGGTGATCGTCGGCTGTCCCAGTTGGCCAATATGGGCACCCGAACCGTTGCG
CTCGCGCTGGTCGATGTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14660.36 Da        Isoelectric Point: 8.7899

>AT36358 WP_085232826.1 NZ_AP022613:c3128263-3127853 [Mycobacterium conspicuum]
MPGAADRVTRFDADLVDSAAAEGARQSRSAKQQLDHWVRVGRAVSAHHTAARRRVEAALVGDIELRELNVEEGVVFNAEI
DAAIQESLAQANYGAVLARRGVTTVALNESGDIVEHRPDGSSIVLAPKRRASRRGR

Download         Length: 411 bp

>AT36358 NZ_AP022613:c3128263-3127853 [Mycobacterium conspicuum]
ATGCCGGGCGCTGCAGATCGGGTGACCCGCTTCGATGCGGACCTCGTCGACAGCGCCGCTGCGGAAGGCGCGCGGCAGAG
CCGGTCGGCCAAGCAGCAGCTCGATCACTGGGTTCGGGTCGGGCGCGCCGTGTCGGCCCACCACACCGCCGCGCGACGTC
GAGTCGAGGCTGCGCTCGTCGGGGACATCGAACTGCGTGAACTCAACGTCGAAGAAGGAGTGGTGTTCAACGCCGAGATC
GATGCCGCGATCCAGGAGAGCCTGGCGCAAGCCAACTATGGCGCGGTGTTGGCCCGGCGCGGCGTCACCACCGTGGCCCT
CAACGAGTCGGGCGATATCGTCGAGCATCGCCCGGATGGCAGCTCCATCGTGCTCGCGCCCAAGCGCCGCGCGTCCCGCC
GCGGAAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References