Detailed information of TA system TA036358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3127262..3128263
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N66_RS14575
• Protein ID: WP_085232825.1
• Coordinates: 3127262..3127840 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G6N66_RS14580
• Protein ID: WP_085232826.1
• Coordinates: 3127853..3128263 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS14555	3124476..3124709	+	234	WP_085232822.1	hypothetical protein	-
G6N66_RS14560	3124706..3125040	+	335	Protein_2890	type II toxin-antitoxin system PemK/MazF family toxin	-
G6N66_RS14565	3125465..3126550	+	1086	WP_085232823.1	hydroxyneurosporene methyltransferase	-
G6N66_RS14570	3126566..3127183	-	618	WP_139825194.1	TetR family transcriptional regulator	-
G6N66_RS14575	3127262..3127840	-	579	WP_085232825.1	zeta toxin family protein	Toxin
G6N66_RS14580	3127853..3128263	-	411	WP_085232826.1	hypothetical protein	Antitoxin
G6N66_RS14585	3128429..3129259	-	831	WP_085232827.1	DUF1906 domain-containing protein	-
G6N66_RS14590	3129615..3129821	+	207	WP_085232828.1	DUF2191 domain-containing protein	-
G6N66_RS14595	3129812..3130234	+	423	WP_085232829.1	PIN domain-containing protein	-
G6N66_RS14600	3131103..3131690	+	588	WP_085232830.1	hypothetical protein	-
G6N66_RS14605	3131675..3132337	+	663	WP_085233006.1	RES family NAD+ phosphorylase	-
G6N66_RS14610	3132398..3133006	+	609	WP_085232831.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-142)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20922.86 Da
• Isoelectric Point: 7.0631

>T36358 WP_085232825.1 NZ_AP022613:c3127840-3127262 [Mycobacterium conspicuum]
MNRLDLVVGPNGAGKSTFVELTLAPLLPGSVFVNADEIARQRWPDDPASHAYEAAAVAADTRSRLIELGRSFIAETVFSH
PSKLELIDAAHAGGYTVVLHVLLIPEELAVQRVRHRASAGGHDVPEDKIRERYQRLWALVAAAITRSDSATVYDNSTLKG
PRIVAQLSSGVIVGCPSWPIWAPEPLRSRWSM

Nucleotide

• Length: 579 bp

>T36358 NZ_AP022613:c3127840-3127262 [Mycobacterium conspicuum]
ATGAACCGGCTCGATCTCGTCGTCGGACCCAACGGTGCCGGCAAGTCGACATTCGTCGAACTCACGCTGGCTCCGCTCCT
ACCCGGCAGCGTGTTCGTCAACGCCGACGAGATCGCCAGACAACGCTGGCCCGACGACCCGGCATCGCATGCGTACGAGG
CCGCGGCGGTTGCCGCCGACACCCGTTCAAGACTGATCGAACTGGGCCGGTCGTTCATCGCGGAAACCGTGTTCTCCCAC
CCGTCGAAGCTCGAGCTGATCGACGCCGCCCACGCGGGGGGCTACACCGTTGTTCTGCACGTGCTGCTGATCCCCGAAGA
ATTGGCCGTGCAACGCGTCAGGCACCGGGCCAGCGCCGGCGGCCACGATGTGCCCGAGGATAAGATTCGCGAACGCTATC
AACGCCTCTGGGCTCTCGTCGCTGCCGCGATCACCCGATCCGACTCGGCGACCGTCTACGACAACAGCACCCTGAAGGGC
CCCCGCATTGTGGCGCAGCTGAGCTCTGGGGTGATCGTCGGCTGTCCCAGTTGGCCAATATGGGCACCCGAACCGTTGCG
CTCGCGCTGGTCGATGTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14660.36 Da
• Isoelectric Point: 8.7899

>AT36358 WP_085232826.1 NZ_AP022613:c3128263-3127853 [Mycobacterium conspicuum]
MPGAADRVTRFDADLVDSAAAEGARQSRSAKQQLDHWVRVGRAVSAHHTAARRRVEAALVGDIELRELNVEEGVVFNAEI
DAAIQESLAQANYGAVLARRGVTTVALNESGDIVEHRPDGSSIVLAPKRRASRRGR

Nucleotide

• Length: 411 bp

>AT36358 NZ_AP022613:c3128263-3127853 [Mycobacterium conspicuum]
ATGCCGGGCGCTGCAGATCGGGTGACCCGCTTCGATGCGGACCTCGTCGACAGCGCCGCTGCGGAAGGCGCGCGGCAGAG
CCGGTCGGCCAAGCAGCAGCTCGATCACTGGGTTCGGGTCGGGCGCGCCGTGTCGGCCCACCACACCGCCGCGCGACGTC
GAGTCGAGGCTGCGCTCGTCGGGGACATCGAACTGCGTGAACTCAACGTCGAAGAAGGAGTGGTGTTCAACGCCGAGATC
GATGCCGCGATCCAGGAGAGCCTGGCGCAAGCCAACTATGGCGCGGTGTTGGCCCGGCGCGGCGTCACCACCGTGGCCCT
CAACGAGTCGGGCGATATCGTCGAGCATCGCCCGGATGGCAGCTCCATCGTGCTCGCGCCCAAGCGCCGCGCGTCCCGCC
GCGGAAGGTAG