Detailed information of TA system TA036357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 2490407..2491395
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: -
• Locus tag: G6N66_RS11745
• Protein ID: WP_085234301.1
• Coordinates: 2490664..2491395 (-)
• Length: 244 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: -
• Locus tag: G6N66_RS11740
• Protein ID: WP_085234302.1
• Coordinates: 2490407..2490667 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS11725	2486751..2488580	-	1830	WP_163645823.1	PE family protein	-
G6N66_RS11730	2488829..2489275	-	447	WP_085234304.1	hypothetical protein	-
G6N66_RS11735	2489636..2490361	+	726	WP_085234303.1	hypothetical protein	-
G6N66_RS11740	2490407..2490667	-	261	WP_085234302.1	hypothetical protein	Antitoxin
G6N66_RS11745	2490664..2491395	-	732	WP_085234301.1	RelA/SpoT domain-containing protein	Toxin
G6N66_RS11750	2491397..2491711	-	315	WP_085234300.1	hypothetical protein	-
G6N66_RS11755	2491708..2492421	-	714	WP_085234299.1	hypothetical protein	-
G6N66_RS11760	2492498..2492725	-	228	WP_085234298.1	hypothetical protein	-
G6N66_RS11765	2492850..2493086	-	237	WP_085234297.1	helix-turn-helix domain-containing protein	-
G6N66_RS11770	2493295..2494503	+	1209	WP_085234296.1	site-specific integrase	-
G6N66_RS11780	2494779..2495402	+	624	WP_085234295.1	ANTAR domain-containing response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (82-179)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 244 a.a.
• Molecular weight: 27032.00 Da
• Isoelectric Point: 10.4190

>T36357 WP_085234301.1 NZ_AP022613:c2491395-2490664 [Mycobacterium conspicuum]
VPASVPSVSAVNRAGDVLRNLRVSGNRIKVSGAVEITPEQIFAALDTLEAWRAAHARPLGAATMGLRSRVATMGCADIEV
SQRLKRIPTIIDKLRREPRMNLGRMHDIGGCRAVLRSLDEVRRVQSRYKGETVTVRTKDYVDQPKPDGYRAVHVIVRYHG
RLIEVQLRTQVQHEWAYTVESVTSRFGLDIKAGGGPPPVRDWFAAVSEAMALEEHGQTVGPELLHRVYTLRDAAQPYLQG
VNR

Nucleotide

• Length: 732 bp

>T36357 NZ_AP022613:c2491395-2490664 [Mycobacterium conspicuum]
GTGCCTGCGTCCGTGCCGAGCGTCTCCGCGGTGAACCGCGCTGGTGACGTCTTGCGCAACCTGCGGGTGAGCGGAAATCG
GATCAAGGTCTCTGGCGCGGTCGAGATCACACCCGAGCAGATCTTCGCCGCATTGGACACGCTGGAAGCGTGGCGCGCAG
CGCATGCGCGCCCCCTCGGCGCTGCAACGATGGGGCTGCGGTCACGCGTTGCGACGATGGGCTGTGCAGATATCGAGGTC
TCCCAGCGGTTGAAACGCATTCCGACGATCATTGACAAACTCCGTCGTGAGCCCCGCATGAATCTCGGGCGGATGCACGA
CATCGGCGGCTGCCGCGCCGTTCTCCGAAGCCTGGATGAAGTTCGGCGCGTCCAATCCCGCTACAAGGGCGAAACTGTGA
CGGTCAGGACCAAAGACTACGTTGACCAGCCGAAACCGGACGGATATCGAGCTGTCCATGTGATCGTCCGATACCACGGC
CGGCTGATTGAAGTGCAGTTGCGCACACAGGTCCAGCACGAGTGGGCCTACACTGTCGAGAGCGTCACATCTCGGTTCGG
ACTCGATATCAAAGCTGGCGGGGGACCACCACCGGTGCGGGACTGGTTTGCGGCAGTGTCGGAGGCAATGGCGCTCGAAG
AACACGGCCAAACCGTGGGCCCAGAGCTTTTACATCGGGTATATACACTGAGAGACGCCGCCCAACCCTATCTGCAAGGA
GTCAATCGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9597.94 Da
• Isoelectric Point: 6.2163

>AT36357 WP_085234302.1 NZ_AP022613:c2490667-2490407 [Mycobacterium conspicuum]
MTASQLKHFLLVFDHNRAQLVDLKEFGTDAKSAMAEYARLERAQMKKESDSIEIVLIGSDSLETVKVTHANYFDGTVAVS
KYFAGI

Nucleotide

• Length: 261 bp

>AT36357 NZ_AP022613:c2490667-2490407 [Mycobacterium conspicuum]
ATGACTGCATCGCAGCTCAAGCACTTCTTGCTCGTGTTCGACCACAACCGCGCCCAGCTGGTCGACCTCAAAGAGTTCGG
CACGGACGCCAAGAGCGCGATGGCTGAGTATGCCCGGCTAGAACGTGCGCAGATGAAGAAGGAGTCGGACTCGATCGAAA
TCGTGCTGATCGGCTCAGACTCGCTGGAAACCGTGAAGGTTACCCACGCGAATTACTTCGATGGCACGGTTGCAGTTTCG
AAGTACTTCGCAGGCATCTAA