36356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2313236..2313846 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS11165 Protein ID WP_085235245.1
Coordinates 2313445..2313846 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS11160 Protein ID WP_179968272.1
Coordinates 2313236..2313445 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS11140 2309402..2309839 + 438 WP_085235241.1 nitroreductase family deazaflavin-dependent oxidoreductase -
G6N66_RS11145 2309874..2311154 + 1281 WP_085235242.1 threonine ammonia-lyase -
G6N66_RS11150 2311186..2311869 - 684 WP_085235243.1 pyridoxamine 5'-phosphate oxidase family protein -
G6N66_RS11155 2311899..2313215 + 1317 WP_085235244.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
G6N66_RS11160 2313236..2313445 + 210 WP_179968272.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N66_RS11165 2313445..2313846 + 402 WP_085235245.1 PIN domain nuclease Toxin
G6N66_RS11170 2313860..2314291 - 432 WP_085235246.1 hypothetical protein -
G6N66_RS11175 2314328..2314981 - 654 WP_085235247.1 class I SAM-dependent methyltransferase -
G6N66_RS11180 2314978..2315550 - 573 WP_085235290.1 mismatch-specific DNA-glycosylase -
G6N66_RS11185 2315612..2317357 - 1746 WP_085235291.1 malto-oligosyltrehalose trehalohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14463.64 Da        Isoelectric Point: 5.6466

>T36356 WP_085235245.1 NZ_AP022613:2313445-2313846 [Mycobacterium conspicuum]
MILIDTSAWIEYFRATGSTAAREVRRLLSDGIEQIAMCEPIAMEILCGATNDTHPTLERLINGLPSLAVENAVDFRAAAD
IYRAARRAGKTIRSINDCLIAAVAIRHNARVVHCDADFDVIAQIASLEAAAIR

Download         Length: 402 bp

>T36356 NZ_AP022613:2313445-2313846 [Mycobacterium conspicuum]
ATGATCCTGATCGACACGTCCGCCTGGATCGAATACTTCCGCGCCACCGGATCCACCGCCGCACGCGAGGTACGCCGGCT
GCTCTCGGACGGCATCGAACAGATTGCGATGTGTGAACCCATTGCCATGGAGATCTTGTGCGGAGCGACCAACGACACTC
ACCCGACGCTCGAACGCCTCATCAACGGGCTGCCCTCGCTGGCTGTCGAAAATGCAGTCGATTTCCGTGCCGCCGCGGAT
ATCTATCGTGCTGCCCGGCGTGCTGGCAAGACAATTCGAAGCATCAACGACTGTCTCATTGCCGCGGTAGCGATCCGCCA
CAATGCCCGGGTTGTCCACTGCGACGCAGACTTCGATGTCATTGCGCAAATAGCCAGCCTCGAGGCGGCCGCGATTCGGT
GA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7746.84 Da        Isoelectric Point: 4.4091

>AT36356 WP_179968272.1 NZ_AP022613:2313236-2313445 [Mycobacterium conspicuum]
MSRTNIDIDDELAAEVMRRFGLSTKKAAVDLALRRLVGLPLTREFLLGLEGVGWEGDLDDVRSEQPDKF

Download         Length: 210 bp

>AT36356 NZ_AP022613:2313236-2313445 [Mycobacterium conspicuum]
ATGTCACGCACAAACATCGACATCGATGACGAACTTGCCGCGGAGGTAATGCGCAGGTTCGGCCTCTCCACGAAGAAGGC
GGCGGTCGATTTGGCGTTGCGACGTCTGGTTGGCTTGCCCCTGACCCGTGAGTTCCTGCTCGGACTCGAAGGAGTCGGCT
GGGAGGGTGACCTCGATGACGTGCGAAGCGAACAGCCCGACAAATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References