Detailed information of TA system TA036355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2200497..2201200
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N66_RS10715
• Protein ID: WP_085232579.1
• Coordinates: 2200497..2200946 (-)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N66_RS10720
• Protein ID: WP_085232580.1
• Coordinates: 2200940..2201200 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS28995	2195916..2196839	-	924	WP_085232574.1	hypothetical protein	-
G6N66_RS10695	2197259..2198278	+	1020	WP_085232575.1	type I glyceraldehyde-3-phosphate dehydrogenase	-
G6N66_RS10700	2198281..2199516	+	1236	WP_085232576.1	phosphoglycerate kinase	-
G6N66_RS10705	2199513..2200298	+	786	WP_085232577.1	triose-phosphate isomerase	-
G6N66_RS10710	2200329..2200562	+	234	WP_085232578.1	preprotein translocase subunit SecG	-
G6N66_RS10715	2200497..2200946	-	450	WP_085232579.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N66_RS10720	2200940..2201200	-	261	WP_085232580.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
G6N66_RS10725	2201294..2204101	+	2808	WP_085232581.1	phosphoenolpyruvate carboxylase	-
G6N66_RS10730	2204126..2205403	-	1278	WP_163645813.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16254.00 Da
• Isoelectric Point: 4.0812

>T36355 WP_085232579.1 NZ_AP022613:c2200946-2200497 [Mycobacterium conspicuum]
MVIDTSALVAMLTDEPEAEHLELAVETDQVRLMSVASYVETAIVIETRFGDPGGRELDLWLHRAAVDLVNVDSDQADIAR
VAYRTYGKGRHRAGLNYGECFSYALAKISGQPLLFKGDDFAHTDIRVVSAVLDEQGNADDADQPDAGDE

Nucleotide

• Length: 450 bp

>T36355 NZ_AP022613:c2200946-2200497 [Mycobacterium conspicuum]
ATGGTGATCGACACTTCGGCGTTGGTCGCGATGCTCACCGACGAGCCCGAGGCAGAGCATCTGGAATTAGCCGTAGAGAC
AGACCAGGTCCGGCTGATGTCGGTGGCGTCATATGTGGAAACGGCGATCGTGATCGAGACGCGCTTCGGTGATCCCGGGG
GGCGCGAGCTGGATTTGTGGCTACATCGTGCAGCGGTCGACCTGGTCAACGTCGATTCAGACCAAGCGGACATCGCCCGG
GTCGCCTACCGCACGTACGGCAAGGGCCGGCACCGCGCCGGTCTGAACTATGGCGAGTGCTTCTCTTACGCCCTGGCGAA
GATTAGTGGCCAACCCCTGCTTTTTAAGGGAGATGACTTCGCGCACACCGATATTCGCGTTGTTTCAGCGGTACTTGATG
AGCAGGGCAACGCCGATGATGCAGACCAGCCAGATGCCGGTGATGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9326.71 Da
• Isoelectric Point: 6.3319

>AT36355 WP_085232580.1 NZ_AP022613:c2201200-2200940 [Mycobacterium conspicuum]
MALSIKDSEADRLARELAARTGETLTQAVVVALRERLARETGRAKPIALREELAAIRRRCAALPILDSRAADEILGYDDA
GLPGAW

Nucleotide

• Length: 261 bp

>AT36355 NZ_AP022613:c2201200-2200940 [Mycobacterium conspicuum]
ATGGCGCTAAGCATCAAAGATTCCGAAGCCGACCGGCTGGCCAGGGAACTCGCCGCTCGCACGGGCGAGACCTTGACCCA
AGCCGTCGTGGTCGCGTTGCGGGAGCGACTCGCCCGCGAGACCGGGCGCGCCAAGCCCATCGCGCTGCGCGAGGAGCTGG
CCGCCATCCGGCGCCGCTGCGCGGCCTTGCCTATCCTCGACAGCCGCGCTGCGGACGAGATTCTCGGTTACGACGACGCT
GGGTTGCCCGGCGCATGGTGA