Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2200497..2201200 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS10715 Protein ID WP_085232579.1
Coordinates 2200497..2200946 (-) Length 150 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS10720 Protein ID WP_085232580.1
Coordinates 2200940..2201200 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS28995 2195916..2196839 - 924 WP_085232574.1 hypothetical protein -
G6N66_RS10695 2197259..2198278 + 1020 WP_085232575.1 type I glyceraldehyde-3-phosphate dehydrogenase -
G6N66_RS10700 2198281..2199516 + 1236 WP_085232576.1 phosphoglycerate kinase -
G6N66_RS10705 2199513..2200298 + 786 WP_085232577.1 triose-phosphate isomerase -
G6N66_RS10710 2200329..2200562 + 234 WP_085232578.1 preprotein translocase subunit SecG -
G6N66_RS10715 2200497..2200946 - 450 WP_085232579.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS10720 2200940..2201200 - 261 WP_085232580.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N66_RS10725 2201294..2204101 + 2808 WP_085232581.1 phosphoenolpyruvate carboxylase -
G6N66_RS10730 2204126..2205403 - 1278 WP_163645813.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16254.00 Da        Isoelectric Point: 4.0812

>T36355 WP_085232579.1 NZ_AP022613:c2200946-2200497 [Mycobacterium conspicuum]
MVIDTSALVAMLTDEPEAEHLELAVETDQVRLMSVASYVETAIVIETRFGDPGGRELDLWLHRAAVDLVNVDSDQADIAR
VAYRTYGKGRHRAGLNYGECFSYALAKISGQPLLFKGDDFAHTDIRVVSAVLDEQGNADDADQPDAGDE

Download         Length: 450 bp

>T36355 NZ_AP022613:c2200946-2200497 [Mycobacterium conspicuum]
ATGGTGATCGACACTTCGGCGTTGGTCGCGATGCTCACCGACGAGCCCGAGGCAGAGCATCTGGAATTAGCCGTAGAGAC
AGACCAGGTCCGGCTGATGTCGGTGGCGTCATATGTGGAAACGGCGATCGTGATCGAGACGCGCTTCGGTGATCCCGGGG
GGCGCGAGCTGGATTTGTGGCTACATCGTGCAGCGGTCGACCTGGTCAACGTCGATTCAGACCAAGCGGACATCGCCCGG
GTCGCCTACCGCACGTACGGCAAGGGCCGGCACCGCGCCGGTCTGAACTATGGCGAGTGCTTCTCTTACGCCCTGGCGAA
GATTAGTGGCCAACCCCTGCTTTTTAAGGGAGATGACTTCGCGCACACCGATATTCGCGTTGTTTCAGCGGTACTTGATG
AGCAGGGCAACGCCGATGATGCAGACCAGCCAGATGCCGGTGATGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9326.71 Da        Isoelectric Point: 6.3319

>AT36355 WP_085232580.1 NZ_AP022613:c2201200-2200940 [Mycobacterium conspicuum]
MALSIKDSEADRLARELAARTGETLTQAVVVALRERLARETGRAKPIALREELAAIRRRCAALPILDSRAADEILGYDDA
GLPGAW

Download         Length: 261 bp

>AT36355 NZ_AP022613:c2201200-2200940 [Mycobacterium conspicuum]
ATGGCGCTAAGCATCAAAGATTCCGAAGCCGACCGGCTGGCCAGGGAACTCGCCGCTCGCACGGGCGAGACCTTGACCCA
AGCCGTCGTGGTCGCGTTGCGGGAGCGACTCGCCCGCGAGACCGGGCGCGCCAAGCCCATCGCGCTGCGCGAGGAGCTGG
CCGCCATCCGGCGCCGCTGCGCGGCCTTGCCTATCCTCGACAGCCGCGCTGCGGACGAGATTCTCGGTTACGACGACGCT
GGGTTGCCCGGCGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References