Detailed information of TA system TA036354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1851484..1852028
• Replicon: chromosome
• Accession: NZ_AP022613
• Organism: Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G6N66_RS09085
• Protein ID: WP_085233073.1
• Coordinates: 1851732..1852028 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1X1TC43
• Locus tag: G6N66_RS09080
• Protein ID: WP_066911550.1
• Coordinates: 1851484..1851735 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N66_RS09065	1846603..1848939	+	2337	WP_163645799.1	hypothetical protein	-
G6N66_RS09070	1849323..1850159	+	837	WP_085235141.1	hypothetical protein	-
G6N66_RS09075	1850226..1851335	+	1110	WP_163645800.1	hypothetical protein	-
G6N66_RS09080	1851484..1851735	+	252	WP_066911550.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G6N66_RS09085	1851732..1852028	+	297	WP_085233073.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N66_RS29095	1852280..1853311	+	1032	WP_085233072.1	C40 family peptidase	-
G6N66_RS09095	1853350..1854870	+	1521	WP_085233071.1	type VII secretion protein EccB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (2-79)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11625.08 Da
• Isoelectric Point: 6.0759

>T36354 WP_085233073.1 NZ_AP022613:1851732-1852028 [Mycobacterium conspicuum]
VNRYVLSPAARADLEQIWDYTCQRWDDDQAEEYVREIQRAIERVVDNPMIGRACDELRPGYRKHAVGSHTLYYRIVTGDV
INVVRILHQRMDVDRHLD

Nucleotide

• Length: 297 bp

>T36354 NZ_AP022613:1851732-1852028 [Mycobacterium conspicuum]
GTGAACCGGTATGTACTTTCGCCCGCCGCCCGCGCCGACCTGGAACAGATCTGGGATTACACCTGCCAGCGCTGGGATGA
CGATCAGGCCGAGGAATACGTCCGTGAAATCCAGCGCGCGATCGAACGAGTGGTCGACAATCCTATGATCGGACGGGCCT
GCGACGAACTCCGCCCTGGCTACCGGAAGCACGCTGTTGGATCGCACACGCTCTACTACCGGATTGTCACCGGCGACGTG
ATCAATGTGGTGCGCATACTCCACCAACGGATGGATGTCGACCGGCACCTCGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9558.54 Da
• Isoelectric Point: 7.0173

>AT36354 WP_066911550.1 NZ_AP022613:1851484-1851735 [Mycobacterium conspicuum]
VGKNTSFSLDEHYSAFIDEEVASGRYRSASDVVRSALRLLEDRETRLRALRQALDAGERSGEPTPFDFDEFVARKRAEQP
RRR

Nucleotide

• Length: 252 bp

>AT36354 NZ_AP022613:1851484-1851735 [Mycobacterium conspicuum]
GTGGGCAAGAATACGTCCTTCAGCCTCGACGAGCATTACAGCGCATTCATCGATGAGGAGGTGGCGTCGGGCCGTTACCG
CTCGGCCAGTGACGTCGTGCGTTCTGCTCTGCGGCTGCTTGAGGATCGTGAGACCCGCCTGCGCGCATTGCGCCAGGCAC
TCGACGCCGGCGAACGAAGTGGTGAGCCGACACCATTCGACTTCGATGAGTTCGTTGCGCGCAAGCGAGCTGAGCAACCT
CGCCGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X1TC43