36353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2410121..2411123 Replicon chromosome
Accession NZ_AP022612
Organism Mycolicibacterium confluentis strain JCM 13671

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N34_RS11150 Protein ID WP_085150992.1
Coordinates 2410121..2410711 (-) Length 197 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N34_RS11155 Protein ID WP_085150993.1
Coordinates 2410734..2411123 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N34_RS11125 2405397..2407097 - 1701 WP_085150987.1 FAD-dependent oxidoreductase -
G6N34_RS11130 2407100..2407597 - 498 WP_085150988.1 AbfB domain-containing protein -
G6N34_RS11135 2407700..2408650 - 951 WP_085150989.1 alpha/beta hydrolase -
G6N34_RS11140 2408800..2409636 + 837 WP_085150990.1 enoyl-CoA hydratase/isomerase family protein -
G6N34_RS11145 2409652..2410089 - 438 WP_085150991.1 hypothetical protein -
G6N34_RS11150 2410121..2410711 - 591 WP_085150992.1 zeta toxin family protein Toxin
G6N34_RS11155 2410734..2411123 - 390 WP_085150993.1 hypothetical protein Antitoxin
G6N34_RS11160 2411199..2411978 - 780 WP_085150994.1 isoprenylcysteine carboxylmethyltransferase family protein -
G6N34_RS11165 2412093..2412563 - 471 WP_085150995.1 SRPBCC domain-containing protein -
G6N34_RS11170 2412560..2412901 - 342 WP_085150996.1 metalloregulator ArsR/SmtB family transcription factor -
G6N34_RS11175 2413088..2413387 - 300 WP_085150997.1 thiamine-binding protein -
G6N34_RS11180 2413394..2413783 - 390 WP_085150998.1 PPOX class F420-dependent oxidoreductase -
G6N34_RS11185 2413943..2415505 + 1563 WP_085150999.1 alpha/beta hydrolase -
G6N34_RS11190 2415584..2415727 + 144 WP_163645368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 21436.48 Da        Isoelectric Point: 9.8735

>T36353 WP_085150992.1 NZ_AP022612:c2410711-2410121 [Mycolicibacterium confluentis]
VKRLDLVVGPNGAGKSTFIAFTLAPVLPRSVFVNADEIAKQRWPDDPLGHAYDAARVAADTRAKLIEAGASFIAETVFSH
PSKLDLIRSAHNAGYTVALHVVLIPEDLAVERVKRRVLHGGHDVPEDKIRERHRRLWQLVAEAIPMADSATVYDNSRREG
PRIVAQFTAGAVIGAAKWPTWASEELVSRWPAAGAR

Download         Length: 591 bp

>T36353 NZ_AP022612:c2410711-2410121 [Mycolicibacterium confluentis]
GTGAAACGGCTCGACCTCGTTGTCGGCCCGAACGGCGCTGGCAAGTCGACGTTCATCGCGTTCACCTTGGCGCCGGTGTT
GCCGCGCAGCGTGTTCGTCAACGCCGACGAGATCGCAAAACAGCGTTGGCCCGACGACCCCCTCGGGCACGCCTACGACG
CGGCGCGCGTCGCGGCAGACACCCGCGCCAAGCTCATCGAGGCCGGAGCGTCGTTCATCGCCGAGACCGTCTTCTCCCAT
CCGTCAAAGCTGGACCTGATCCGCTCGGCCCACAATGCGGGCTACACCGTCGCCCTGCATGTGGTGCTGATTCCGGAGGA
TCTCGCCGTCGAGCGCGTAAAGCGGCGAGTCCTCCACGGCGGTCACGACGTCCCCGAGGACAAGATCCGCGAACGACACC
GCCGACTGTGGCAGTTGGTGGCCGAAGCGATTCCCATGGCGGACAGCGCCACTGTCTACGACAACTCCCGGCGCGAGGGG
CCCCGCATCGTCGCGCAGTTCACGGCGGGCGCGGTCATCGGCGCTGCGAAGTGGCCGACGTGGGCATCCGAGGAGCTGGT
CAGTCGATGGCCTGCTGCCGGCGCCCGCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13788.96 Da        Isoelectric Point: 4.4234

>AT36353 WP_085150993.1 NZ_AP022612:c2411123-2410734 [Mycolicibacterium confluentis]
MTNVADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSHQTASRHRVEAALAGRLDTNDLSEDEGLVFNAEI
SAAIEESLSTTNYGDTLSARGITTVALNDDGEIVEYRPDGTTAVVDSDR

Download         Length: 390 bp

>AT36353 NZ_AP022612:c2411123-2410734 [Mycolicibacterium confluentis]
ATGACGAACGTCGCCGATCGCGTCACCAGGGTCGCCGCCGACCTGATGGACAGCGCCGCTGCCGAGGGGGCCCGCCAGAG
CCGGTCGGCCAAGCAGCAACTCGATCATTGGGCCCGGGTGGGCCGCGCAGTGTCAAGCCATCAGACGGCTTCGCGCCATC
GAGTCGAGGCCGCGCTGGCCGGCCGCCTGGACACCAACGACCTGTCCGAGGACGAGGGTCTGGTGTTCAACGCGGAGATC
TCGGCCGCCATCGAGGAGTCCCTGTCCACCACCAACTACGGGGACACCCTGTCGGCGCGGGGCATCACGACGGTGGCGCT
CAACGACGACGGCGAGATCGTCGAGTACCGTCCCGACGGCACCACCGCGGTGGTCGACTCCGACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References