36349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 816396..817071 Replicon chromosome
Accession NZ_AP022610
Organism Mycolicibacterium madagascariense strain JCM 13574

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N60_RS03755 Protein ID WP_163732757.1
Coordinates 816670..817071 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N60_RS03750 Protein ID WP_163732755.1
Coordinates 816396..816662 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N60_RS03730 811648..813141 + 1494 WP_163732746.1 M20/M25/M40 family metallo-hydrolase -
G6N60_RS03735 813138..814586 + 1449 WP_163732748.1 M28 family peptidase -
G6N60_RS03740 814659..815066 + 408 WP_163732750.1 hypothetical protein -
G6N60_RS03745 815063..816397 - 1335 WP_163732752.1 nitrate reductase -
G6N60_RS03750 816396..816662 + 267 WP_163732755.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N60_RS03755 816670..817071 + 402 WP_163732757.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N60_RS03760 817064..817921 - 858 WP_163732759.1 LLM class F420-dependent oxidoreductase -
G6N60_RS03765 817940..818374 - 435 WP_163732761.1 MarR family transcriptional regulator -
G6N60_RS03770 818407..819420 - 1014 WP_163732763.1 NAD(P)-dependent alcohol dehydrogenase -
G6N60_RS03775 819446..820288 - 843 WP_163732765.1 polysaccharide deacetylase family protein -
G6N60_RS03780 820427..820696 - 270 WP_170312543.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14149.26 Da        Isoelectric Point: 5.1617

>T36349 WP_163732757.1 NZ_AP022610:816670-817071 [Mycolicibacterium madagascariense]
MRLYLDTSALVKLVVEEPETAALQAFLDASPDDALFTAALSRIELMRAVGRAGDAARAQARARALLDAVDTVALSRTLLD
DAGLLGPERLRSLDAIHLAAAMRAGTTLRSVVTYDLRMADAAQRLGMQTSAPN

Download         Length: 402 bp

>T36349 NZ_AP022610:816670-817071 [Mycolicibacterium madagascariense]
ATGCGGCTCTATCTGGACACCTCCGCTCTCGTCAAGCTCGTCGTCGAGGAGCCCGAAACCGCTGCGCTGCAAGCATTCCT
GGACGCGTCGCCCGACGACGCCCTGTTCACCGCGGCGCTGTCACGCATCGAGTTGATGCGCGCCGTCGGCCGCGCCGGCG
ACGCCGCACGAGCGCAGGCGCGGGCGCGGGCGCTGCTGGACGCGGTGGACACCGTCGCGCTCTCACGGACACTTCTCGAC
GACGCGGGACTCCTTGGGCCAGAACGCCTTCGGAGCCTGGACGCGATTCATCTCGCTGCCGCGATGCGGGCGGGGACCAC
CTTGCGCAGCGTGGTCACCTACGACCTCCGCATGGCCGATGCTGCGCAGCGGCTCGGGATGCAGACCTCGGCGCCTAACT
GA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9749.84 Da        Isoelectric Point: 4.8605

>AT36349 WP_163732755.1 NZ_AP022610:816396-816662 [Mycolicibacterium madagascariense]
MEEIGVRELRQHASRYLRRVAAGETIEVTDRGRPVARLVPITGDPWQDLIDAGEVQPGSGREAMSGITPRDYGFSASRAL
DDLRDGER

Download         Length: 267 bp

>AT36349 NZ_AP022610:816396-816662 [Mycolicibacterium madagascariense]
ATGGAGGAGATTGGTGTCAGGGAGTTGCGTCAGCACGCCAGCCGGTACCTCCGACGGGTCGCGGCCGGGGAGACGATCGA
AGTGACCGACCGAGGCCGCCCGGTTGCCCGCCTGGTGCCCATCACCGGCGACCCGTGGCAAGACCTGATCGACGCCGGCG
AGGTGCAGCCGGGCTCCGGACGCGAGGCCATGTCCGGCATCACGCCGCGCGACTACGGTTTCAGCGCCTCCCGCGCCCTC
GACGACCTCCGCGACGGTGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References