Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1622624..1623159 Replicon chromosome
Accession NZ_AP022609
Organism Mycolicibacter hiberniae strain JCM 13571

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N14_RS07580 Protein ID WP_085135322.1
Coordinates 1622827..1623159 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N14_RS07575 Protein ID WP_085135321.1
Coordinates 1622624..1622830 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N14_RS07545 1617713..1618579 + 867 WP_085135316.1 alpha/beta hydrolase -
G6N14_RS20525 1618751..1618897 + 147 WP_109559768.1 hypothetical protein -
G6N14_RS20530 1618905..1619063 - 159 WP_170307439.1 hypothetical protein -
G6N14_RS07555 1619107..1620783 - 1677 WP_085135317.1 GMC family oxidoreductase N-terminal domain-containing protein -
G6N14_RS07560 1620949..1621386 - 438 WP_085135318.1 MOSC domain-containing protein -
G6N14_RS07565 1621540..1621749 - 210 WP_085135319.1 hypothetical protein -
G6N14_RS07570 1621849..1622400 - 552 WP_085135320.1 YaeQ family protein -
G6N14_RS07575 1622624..1622830 + 207 WP_085135321.1 DUF3018 family protein Antitoxin
G6N14_RS07580 1622827..1623159 + 333 WP_085135322.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N14_RS07585 1623568..1624401 - 834 WP_085135323.1 acetolactate decarboxylase -
G6N14_RS07590 1624408..1626072 - 1665 WP_109559769.1 acetolactate synthase AlsS -
G6N14_RS07595 1626738..1627328 + 591 WP_085135325.1 DUF3253 domain-containing protein -
G6N14_RS07600 1627442..1627918 + 477 WP_085135326.1 nitroreductase family deazaflavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1606211..1632953 26742


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11804.61 Da        Isoelectric Point: 7.2041

>T36348 WP_085135322.1 NZ_AP022609:1622827-1623159 [Mycolicibacter hiberniae]
VNRGEIWTVAGGVYAAKPRPAVIIQDDLFDGTSSVTVAPMTSALLDAPLMRIRIAGGGDRLSGLDHDSDVMVDKLTTVRR
SSVHSRLGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

>T36348 NZ_AP022609:1622827-1623159 [Mycolicibacter hiberniae]
GTGAACCGAGGGGAGATCTGGACCGTGGCGGGTGGCGTCTATGCCGCGAAGCCGCGTCCCGCGGTGATCATCCAAGACGA
CCTGTTCGACGGTACGAGTTCAGTGACTGTCGCTCCGATGACCAGCGCGCTGTTGGATGCGCCGCTGATGCGTATTCGGA
TAGCCGGCGGCGGCGACCGGCTATCCGGACTGGACCACGACAGCGACGTGATGGTCGATAAGCTCACAACCGTCAGAAGG
TCGAGCGTTCATTCCCGACTGGGTCGGTTGACAGCGGAGCAAGTCGTCGAGGTCGAGCGAGCGATGATGGCATTCCTTGG
CCTTGCCCGATAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7898.75 Da        Isoelectric Point: 4.6412

>AT36348 WP_085135321.1 NZ_AP022609:1622624-1622830 [Mycolicibacter hiberniae]
MAVRERVGEYRRRMRERGLRPLQVWVPDVRTETFAAEAHRQASLLARADEAGDDQDFIEGVSAPWDEE

Download         Length: 207 bp

>AT36348 NZ_AP022609:1622624-1622830 [Mycolicibacter hiberniae]
ATGGCCGTGAGGGAGAGGGTCGGCGAGTACCGACGGCGGATGCGGGAGCGGGGCCTCCGGCCGCTGCAGGTCTGGGTGCC
TGATGTTCGGACGGAGACGTTTGCGGCCGAGGCGCATCGCCAGGCTTCGTTGCTCGCACGGGCGGACGAGGCCGGCGACG
ACCAAGATTTCATTGAGGGCGTGTCTGCGCCATGGGATGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References