Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2989621..2990285 Replicon chromosome
Accession NZ_AP022608
Organism Mycolicibacterium gadium strain JCM 12688

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N36_RS14605 Protein ID WP_163687111.1
Coordinates 2989621..2990031 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N36_RS14610 Protein ID WP_163687112.1
Coordinates 2990028..2990285 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N36_RS14585 2984641..2986218 + 1578 WP_163687107.1 FMN-binding glutamate synthase family protein -
G6N36_RS14590 2986268..2987041 + 774 WP_163687108.1 RsiV family protein -
G6N36_RS14595 2987093..2988703 + 1611 WP_163687109.1 peptide chain release factor 3 -
G6N36_RS14600 2988928..2989614 + 687 WP_163687110.1 sensor domain-containing protein -
G6N36_RS14605 2989621..2990031 - 411 WP_163687111.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N36_RS14610 2990028..2990285 - 258 WP_163687112.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N36_RS14615 2990330..2991055 - 726 WP_163687113.1 hypothetical protein -
G6N36_RS14620 2991284..2991559 + 276 WP_163687114.1 hypothetical protein -
G6N36_RS14625 2991583..2993577 + 1995 WP_163690691.1 hypothetical protein -
G6N36_RS14630 2993574..2993897 + 324 WP_163687115.1 hypothetical protein -
G6N36_RS14635 2994239..2994724 + 486 WP_163687116.1 hypothetical protein -
G6N36_RS14640 2994735..2995229 + 495 WP_163687117.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14435.53 Da        Isoelectric Point: 4.3494

>T36347 WP_163687111.1 NZ_AP022608:c2990031-2989621 [Mycolicibacterium gadium]
VTTDQPAAGILDTSVFIANESGRQLETSLLPEELATTVVTLAELNAGVLAAKTSEIRARRLRTLDAVADMTALPVDEDAA
QMWALLRVHLAEAGRRVRVNDLWIAAIAAAKQLPVVTQDGDFDVLEGVAGLAIVHV

Download         Length: 411 bp

>T36347 NZ_AP022608:c2990031-2989621 [Mycolicibacterium gadium]
GTGACGACCGATCAGCCCGCCGCCGGCATCCTCGACACCTCGGTCTTCATCGCCAACGAGAGCGGGCGCCAACTCGAGAC
ATCGCTGCTTCCAGAGGAACTCGCCACGACTGTGGTGACCCTGGCCGAACTGAACGCGGGCGTGCTCGCGGCGAAGACCT
CCGAGATCCGAGCGCGTCGGCTTCGCACCTTGGATGCCGTCGCCGACATGACGGCGTTACCGGTCGACGAAGACGCGGCT
CAAATGTGGGCGCTGCTACGCGTCCACCTCGCTGAGGCGGGGCGACGGGTCCGAGTCAATGACCTGTGGATCGCGGCAAT
CGCAGCCGCTAAACAGCTGCCCGTCGTCACGCAGGATGGGGACTTCGACGTCCTGGAAGGTGTCGCGGGTCTCGCAATAG
TCCACGTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9440.64 Da        Isoelectric Point: 4.8660

>AT36347 WP_163687112.1 NZ_AP022608:c2990285-2990028 [Mycolicibacterium gadium]
MSTVASRELRNDTAGVLRRVQAGEEVTITVNGRAVAMITAVQPRRRRWVSKGELVKRLETSQADFGLRDDLAELAGETTE
ELDEL

Download         Length: 258 bp

>AT36347 NZ_AP022608:c2990285-2990028 [Mycolicibacterium gadium]
ATGTCAACGGTCGCCTCCCGCGAACTGCGAAACGACACGGCGGGCGTGCTTCGTCGGGTCCAAGCCGGCGAAGAGGTGAC
GATTACGGTGAATGGGCGAGCCGTCGCGATGATCACCGCGGTGCAGCCCAGGCGTCGGCGGTGGGTGTCGAAGGGTGAAT
TGGTCAAGCGGCTCGAGACCAGCCAGGCGGATTTCGGTTTGCGCGATGACCTCGCGGAGCTCGCCGGTGAAACCACCGAG
GAACTCGACGAGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References