Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4613475..4614118 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS22330 Protein ID WP_083132503.1
Coordinates 4613729..4614118 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS22325 Protein ID WP_083132473.1
Coordinates 4613475..4613732 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS22310 4608657..4610426 - 1770 WP_083132476.1 glycoside hydrolase -
G6N47_RS22315 4610471..4611577 + 1107 WP_083132475.1 mandelate racemase -
G6N47_RS22320 4611712..4613430 + 1719 WP_083132474.1 hypothetical protein -
G6N47_RS22325 4613475..4613732 + 258 WP_083132473.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS22330 4613729..4614118 + 390 WP_083132503.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N47_RS22355 4614849..4617821 - 2973 WP_083132472.1 N-6 DNA methylase -
G6N47_RS22360 4618359..4618658 - 300 WP_083132471.1 hypothetical protein -
G6N47_RS22365 4618698..4618982 - 285 WP_083132470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-39)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14331.69 Da        Isoelectric Point: 10.8163

>T36344 WP_083132503.1 NZ_AP022606:4613729-4614118 [Mycobacterium branderi]
VILVDTDVLVAHLRGVAAAHDWLIKSRKDGTLAISVVSIAELIGGMRSAERREVWRLLASFHVEPATEIIARRAGDLMRR
YRRSHNAIGLGDYLIAATADVQGLQLATLNVRHFPMFERLQPPFALPRG

Download         Length: 390 bp

>T36344 NZ_AP022606:4613729-4614118 [Mycobacterium branderi]
GTGATCCTCGTCGATACCGACGTACTAGTCGCCCATTTGCGGGGAGTCGCAGCAGCCCACGACTGGCTGATCAAAAGCCG
CAAGGATGGAACTCTCGCAATCAGCGTGGTGTCGATCGCCGAATTAATCGGTGGGATGAGAAGTGCCGAGCGCCGCGAAG
TGTGGCGCCTGCTCGCGTCCTTTCACGTGGAACCCGCGACCGAAATCATCGCGCGCCGCGCAGGCGATCTGATGCGCCGA
TACCGCAGAAGCCACAACGCGATCGGACTCGGCGACTATCTGATTGCAGCAACCGCCGACGTGCAGGGCCTCCAGTTGGC
GACACTCAACGTGCGGCATTTCCCGATGTTCGAACGCCTGCAGCCACCGTTTGCGCTACCACGTGGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9480.48 Da        Isoelectric Point: 5.1154

>AT36344 WP_083132473.1 NZ_AP022606:4613475-4613732 [Mycobacterium branderi]
MKRRNIYLDEAQTASLDKLADQQGVSRAELIRQLLNRALNNADDDLASDLAAINDSFGALRDFEKPARGPSGREEHLDRV
WRGGS

Download         Length: 258 bp

>AT36344 NZ_AP022606:4613475-4613732 [Mycobacterium branderi]
ATGAAGCGCAGGAACATCTACCTTGATGAAGCGCAGACGGCAAGCCTCGACAAGCTCGCCGACCAGCAAGGGGTGTCGCG
TGCCGAGCTCATCCGCCAACTACTGAACCGGGCCCTCAACAACGCCGACGACGATTTGGCGTCGGACCTCGCAGCAATCA
ACGATTCGTTCGGAGCGCTTCGGGACTTCGAGAAGCCGGCGCGCGGCCCCAGCGGCCGAGAGGAGCACCTCGACCGGGTG
TGGCGCGGCGGATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References