Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 4461345..4461924 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N47_RS21525 Protein ID WP_083134420.1
Coordinates 4461574..4461924 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N47_RS21520 Protein ID WP_083134421.1
Coordinates 4461345..4461581 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS21505 4456957..4458303 - 1347 WP_083134424.1 rRNA cytosine-C5-methyltransferase -
G6N47_RS21510 4458300..4459226 - 927 WP_083134423.1 methionyl-tRNA formyltransferase -
G6N47_RS21515 4459307..4461259 - 1953 WP_083134422.1 aconitate hydratase -
G6N47_RS21520 4461345..4461581 + 237 WP_083134421.1 antitoxin Antitoxin
G6N47_RS21525 4461574..4461924 + 351 WP_083134420.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N47_RS21530 4461994..4463412 - 1419 WP_083134419.1 cytochrome P450 -
G6N47_RS21535 4463529..4465460 - 1932 WP_083134454.1 primosomal protein N' -
G6N47_RS21540 4465511..4466224 - 714 WP_083134418.1 lysoplasmalogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12299.25 Da        Isoelectric Point: 6.2189

>T36343 WP_083134420.1 NZ_AP022606:4461574-4461924 [Mycobacterium branderi]
MPDPQRGDLWLVALGAARAGEPGKHRPAVVVSVDDILTGIEDELIVVVPVSSSVTHNPLRPHISPSEGVDTKSVAVCRGI
RAVARTRLLERLGTVAPDTMDQIERGLALILGIQIA

Download         Length: 351 bp

>T36343 NZ_AP022606:4461574-4461924 [Mycobacterium branderi]
TTGCCTGACCCGCAACGCGGCGACCTTTGGCTCGTCGCCCTGGGCGCCGCCCGCGCCGGCGAACCCGGCAAACACCGCCC
CGCCGTCGTCGTCTCCGTTGACGACATACTCACCGGCATCGAAGACGAACTCATCGTCGTGGTACCGGTGTCGAGCTCAG
TGACCCACAACCCGTTGCGGCCGCACATCTCACCCAGCGAAGGCGTGGACACTAAAAGCGTCGCCGTCTGCCGCGGCATC
CGCGCCGTCGCTCGCACGCGCCTACTGGAGAGACTGGGCACCGTGGCGCCCGACACGATGGACCAGATCGAACGCGGCCT
CGCATTGATTCTGGGCATCCAAATCGCCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8522.52 Da        Isoelectric Point: 5.1088

>AT36343 WP_083134421.1 NZ_AP022606:4461345-4461581 [Mycobacterium branderi]
MSTPTTTIRVPVQTRDKLAAQARERGVSIAALLTELAARAEREAIFRAERDATRAEAALQAVRDENRDWDTTVGDGLA

Download         Length: 237 bp

>AT36343 NZ_AP022606:4461345-4461581 [Mycobacterium branderi]
ATGTCTACTCCAACGACTACTATCAGGGTTCCGGTCCAGACTCGTGACAAGCTAGCCGCCCAGGCCCGCGAGCGAGGTGT
CTCTATCGCTGCGCTGCTAACGGAGCTGGCTGCCCGCGCCGAACGCGAGGCGATCTTCCGCGCCGAGCGGGATGCCACCC
GCGCTGAGGCGGCGCTGCAAGCCGTACGCGATGAGAACCGCGATTGGGACACCACGGTGGGCGACGGCCTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References