Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3902507..3903069 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N47_RS19010 Protein ID WP_083131997.1
Coordinates 3902740..3903069 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N47_RS19005 Protein ID WP_083131857.1
Coordinates 3902507..3902743 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS18975 3897852..3898805 - 954 WP_083131862.1 DUF742 domain-containing protein -
G6N47_RS18980 3899060..3899488 - 429 WP_083131861.1 cellulose-binding domain-containing protein -
G6N47_RS18985 3899557..3900396 - 840 WP_083131860.1 alpha/beta fold hydrolase -
G6N47_RS18990 3900384..3901451 - 1068 WP_163659693.1 phenylacetate--CoA ligase family protein -
G6N47_RS18995 3901461..3901721 + 261 WP_163659695.1 hypothetical protein -
G6N47_RS19000 3901753..3902382 - 630 WP_083131858.1 TetR/AcrR family transcriptional regulator -
G6N47_RS19005 3902507..3902743 + 237 WP_083131857.1 DUF2191 domain-containing protein Antitoxin
G6N47_RS19010 3902740..3903069 + 330 WP_083131997.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N47_RS19015 3903140..3903568 - 429 WP_083131996.1 pyridoxamine 5'-phosphate oxidase family protein -
G6N47_RS19020 3903652..3905172 + 1521 WP_083131856.1 LCP family protein -
G6N47_RS19025 3905192..3906064 - 873 WP_083131995.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11675.68 Da        Isoelectric Point: 8.1274

>T36342 WP_083131997.1 NZ_AP022606:3902740-3903069 [Mycobacterium branderi]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRTLVAPCTTTIRGLASEVVLEPGLDPIPRRSAVNLDSVESVSVA
VLVSRLGRLADTRMRAICAALEVAVDCSG

Download         Length: 330 bp

>T36342 NZ_AP022606:3902740-3903069 [Mycobacterium branderi]
GTGACTGCACTGCCGGCACGCGGAGAGGTGTGGTGGTGCGAGATGGCGGAGATCGGCCGACGCCCGGTTGTGGTGTTGTC
GCGCGACGCGGCGATCCCTCGGCTTCGGCGCACACTCGTCGCTCCGTGCACCACGACCATCCGGGGGCTGGCAAGCGAGG
TCGTCCTTGAACCTGGCCTCGACCCGATCCCCCGGCGTTCGGCGGTGAACCTGGATTCGGTCGAAAGTGTCTCGGTCGCA
GTGTTGGTCAGTCGGCTTGGCCGCCTCGCCGATACCCGGATGCGCGCGATTTGTGCGGCCCTTGAAGTCGCAGTTGATTG
TTCAGGTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8425.27 Da        Isoelectric Point: 4.7640

>AT36342 WP_083131857.1 NZ_AP022606:3902507-3902743 [Mycobacterium branderi]
MRRIRLSTTVDAKLLTAARGLRSGSTDAALIDEALDALLARHRSAEVDASYAAYDEHPADEPDEWGDLASWRRAAGAS

Download         Length: 237 bp

>AT36342 NZ_AP022606:3902507-3902743 [Mycobacterium branderi]
ATGCGTCGCATACGGTTGAGCACCACCGTTGATGCCAAATTGTTGACCGCTGCGCGCGGTCTGCGGTCGGGAAGCACGGA
CGCCGCCCTCATCGATGAGGCTCTCGACGCCCTGCTAGCTCGTCATCGATCGGCTGAAGTAGATGCGAGTTATGCCGCTT
ATGACGAGCACCCGGCTGATGAGCCCGACGAGTGGGGCGACCTGGCCTCGTGGCGGCGAGCCGCTGGCGCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References