Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3886592..3887235 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS18915 Protein ID WP_083131872.1
Coordinates 3886819..3887235 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS18910 Protein ID WP_163659690.1
Coordinates 3886592..3886822 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS18890 3882496..3883401 - 906 WP_139799509.1 SDR family NAD(P)-dependent oxidoreductase -
G6N47_RS18895 3883419..3884057 - 639 WP_163659688.1 TetR/AcrR family transcriptional regulator -
G6N47_RS18900 3884142..3884954 + 813 WP_083131999.1 thioesterase family protein -
G6N47_RS18905 3884968..3885945 - 978 WP_083131874.1 alpha/beta fold hydrolase -
G6N47_RS18910 3886592..3886822 + 231 WP_163659690.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS18915 3886819..3887235 + 417 WP_083131872.1 PIN domain-containing protein Toxin
G6N47_RS18920 3887609..3888316 - 708 WP_083131871.1 hypothetical protein -
G6N47_RS18925 3888424..3888969 + 546 WP_139799495.1 hypothetical protein -
G6N47_RS18930 3889208..3889456 - 249 WP_083131869.1 helix-turn-helix domain-containing protein -
G6N47_RS29335 3889617..3890924 - 1308 WP_179966397.1 hypothetical protein -
G6N47_RS18940 3891566..3891790 + 225 WP_083131868.1 DUF433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-131)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-32)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15879.91 Da        Isoelectric Point: 7.4047

>T36341 WP_083131872.1 NZ_AP022606:3886819-3887235 [Mycobacterium branderi]
VKFADTSWWVAWALPGNARHASALTMLAALGRSEQILTTNLIAGETWTFLRRKDSHRTALAFLDRLDTLQSAERLVVHRV
TEEQDAAAWEWLRKHDERVYSYVDATSFRVMRDRRLREALAFDQDFAAAGFVEVQGTR

Download         Length: 417 bp

>T36341 NZ_AP022606:3886819-3887235 [Mycobacterium branderi]
GTGAAGTTCGCCGACACGAGTTGGTGGGTAGCGTGGGCGCTGCCGGGGAATGCCCGGCACGCCAGCGCACTGACCATGCT
GGCCGCTCTCGGGCGCTCTGAGCAGATCCTCACGACCAACCTCATCGCTGGCGAGACGTGGACCTTCTTGCGTCGCAAGG
ACAGCCATCGGACCGCGCTGGCTTTTCTGGACCGGCTCGATACGCTGCAGAGCGCGGAGCGCCTTGTGGTGCACCGCGTT
ACCGAGGAGCAAGATGCGGCGGCGTGGGAGTGGCTCCGAAAACATGATGAGCGGGTGTACTCCTATGTGGATGCCACGAG
CTTTCGTGTCATGCGTGATCGCCGCTTGCGTGAGGCGTTAGCGTTCGACCAAGACTTCGCTGCGGCCGGCTTCGTGGAAG
TCCAGGGCACGCGGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 7893.93 Da        Isoelectric Point: 4.2850

>AT36341 WP_163659690.1 NZ_AP022606:3886592-3886822 [Mycobacterium branderi]
VKTITITIPEELDALATAEARRRGISKSELIRVGLGAVLSPPLESAADDLWRSLAGFGSAGISAQPGEIDDVVYGT

Download         Length: 231 bp

>AT36341 NZ_AP022606:3886592-3886822 [Mycobacterium branderi]
GTGAAGACGATCACGATCACGATTCCGGAGGAGCTCGATGCACTGGCTACTGCGGAGGCCCGCCGCCGTGGCATATCCAA
ATCCGAGCTCATTCGCGTGGGACTCGGTGCCGTGCTTTCGCCGCCACTTGAGTCCGCTGCAGATGACCTTTGGCGCTCTC
TCGCCGGATTCGGTTCGGCGGGGATTTCCGCGCAACCGGGTGAGATCGACGACGTCGTCTACGGCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References