Detailed information of TA system TA036340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3821676..3822226
• Replicon: chromosome
• Accession: NZ_AP022606
• Organism: Mycobacterium branderi strain JCM 12687

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6N47_RS18655
• Protein ID: WP_083131911.1
• Coordinates: 3821676..3821960 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6N47_RS18660
• Protein ID: WP_083131910.1
• Coordinates: 3821957..3822226 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N47_RS18625	3817037..3817711	+	675	WP_083131916.1	GNAT family N-acetyltransferase	-
G6N47_RS18630	3817734..3818147	-	414	WP_083131915.1	F420-dependent biliverdin reductase	-
G6N47_RS18635	3818183..3818932	+	750	WP_083131914.1	SDR family NAD(P)-dependent oxidoreductase	-
G6N47_RS18640	3819027..3820202	+	1176	WP_083131913.1	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE	-
G6N47_RS18645	3820199..3820954	+	756	WP_083132010.1	precorrin-4 C(11)-methyltransferase	-
G6N47_RS18650	3820954..3821679	+	726	WP_083131912.1	cobalt-precorrin-6A reductase	-
G6N47_RS18655	3821676..3821960	-	285	WP_083131911.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N47_RS18660	3821957..3822226	-	270	WP_083131910.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N47_RS18665	3822351..3825503	+	3153	WP_083131909.1	adenylate/guanylate cyclase domain-containing protein	-
G6N47_RS18670	3825524..3826021	+	498	WP_083132009.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10708.24 Da
• Isoelectric Point: 9.6015

>T36340 WP_083131911.1 NZ_AP022606:c3821960-3821676 [Mycobacterium branderi]
VSDDDHYHVAITATAACDLKRLPEKAAAACVEFIFGSLVENPHRLGKPLRNDLAGLRSARRGDYRVIYLIDDRNRRIAIL
HIARRSDVYRLQTH

Nucleotide

• Length: 285 bp

>T36340 NZ_AP022606:c3821960-3821676 [Mycobacterium branderi]
GTGAGCGACGACGATCACTACCACGTCGCCATCACGGCGACCGCTGCGTGTGACCTTAAGCGCTTACCCGAGAAAGCGGC
CGCCGCGTGCGTCGAATTCATCTTCGGCTCTCTCGTCGAGAACCCCCACAGGTTGGGCAAACCGCTGCGTAACGACCTTG
CGGGTCTGCGCTCGGCTCGTCGCGGCGACTACCGCGTCATCTACCTCATCGACGACCGCAACCGCCGGATCGCGATTCTG
CACATCGCACGCCGTAGTGACGTGTACCGGCTGCAAACCCACTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9707.78 Da
• Isoelectric Point: 5.0827

>AT36340 WP_083131910.1 NZ_AP022606:c3822226-3821957 [Mycobacterium branderi]
MATVPLGEARNHLSEYVADVERTHERVTITRHGHPAAVLISADELASIEETLEVLRTPGAVDAIQQGFADVAAGHFVSND
EIRSRYTAR

Nucleotide

• Length: 270 bp

>AT36340 NZ_AP022606:c3822226-3821957 [Mycobacterium branderi]
ATGGCGACTGTTCCACTGGGTGAGGCACGCAATCATCTTTCGGAATACGTCGCCGACGTTGAGCGGACGCACGAGCGCGT
CACGATCACGCGGCATGGGCATCCCGCCGCGGTACTGATTTCTGCTGACGAACTCGCGTCCATCGAAGAAACACTCGAGG
TGTTGCGCACACCGGGCGCCGTGGATGCGATTCAACAGGGTTTCGCGGATGTGGCAGCCGGACATTTTGTCAGCAATGAC
GAGATCCGCAGCCGCTACACCGCCCGGTGA