Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 3601834..3602465 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS17510 Protein ID WP_083133343.1
Coordinates 3601834..3602211 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS17515 Protein ID WP_083133381.1
Coordinates 3602208..3602465 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS17480 3597886..3599139 + 1254 WP_083133349.1 cytochrome P450 -
G6N47_RS17485 3599132..3599773 + 642 WP_083133348.1 TetR/AcrR family transcriptional regulator -
G6N47_RS17490 3599956..3600312 + 357 WP_083133347.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N47_RS17495 3600326..3600961 + 636 WP_083133346.1 zeta toxin family protein -
G6N47_RS17500 3600974..3601228 - 255 WP_083133345.1 hypothetical protein -
G6N47_RS17505 3601247..3601663 - 417 WP_083133344.1 ferritin-like domain-containing protein -
G6N47_RS17510 3601834..3602211 - 378 WP_083133343.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N47_RS17515 3602208..3602465 - 258 WP_083133381.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS17520 3602613..3603389 + 777 WP_083133342.1 RsiV family protein -
G6N47_RS17525 3603395..3604288 - 894 WP_083133341.1 helix-turn-helix domain-containing protein -
G6N47_RS17530 3604353..3605291 + 939 WP_179966391.1 SDR family oxidoreductase -
G6N47_RS17535 3605288..3606067 + 780 WP_083133340.1 acetoacetate decarboxylase family protein -
G6N47_RS17540 3606070..3607284 + 1215 WP_083133339.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13691.63 Da        Isoelectric Point: 4.9285

>T36339 WP_083133343.1 NZ_AP022606:c3602211-3601834 [Mycobacterium branderi]
VKLLDTTIAVDHLRGEPAAVDFLATVVGSGEDLVASELVRFELHAGVRDKELDALEEFCSALRWAAVTEEIARVAGRLAR
RYRRSHSGIGAVDYVIAATAIVIDADLLTTNVRHFPMFTTLEPPY

Download         Length: 378 bp

>T36339 NZ_AP022606:c3602211-3601834 [Mycobacterium branderi]
GTGAAGCTGCTCGACACGACGATCGCTGTCGACCACTTGCGCGGCGAGCCGGCCGCTGTCGACTTTCTGGCGACGGTTGT
CGGAAGCGGCGAAGACTTAGTAGCAAGCGAATTAGTCCGATTCGAGCTCCATGCAGGCGTACGCGACAAAGAGCTCGATG
CGCTCGAAGAATTCTGCTCTGCCCTGCGTTGGGCCGCAGTAACCGAGGAAATCGCCCGCGTCGCCGGACGGCTTGCCCGT
CGTTACCGACGAAGCCACAGCGGTATCGGTGCTGTTGATTACGTGATCGCGGCCACCGCAATTGTCATCGACGCCGACCT
GCTCACGACCAACGTGCGTCATTTTCCGATGTTCACCACGTTGGAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9409.49 Da        Isoelectric Point: 10.8162

>AT36339 WP_083133381.1 NZ_AP022606:c3602465-3602208 [Mycobacterium branderi]
MRTQITLTDEEVELLDRAARSSGASRSELIRRAIRATYGSGSKEDRVAALKRSAGSWRRRDSTGAEYVDAVRGDLNERLS
RLGLA

Download         Length: 258 bp

>AT36339 NZ_AP022606:c3602465-3602208 [Mycobacterium branderi]
ATGCGCACGCAAATCACCCTGACGGACGAGGAGGTCGAGCTTCTCGATCGCGCCGCACGATCAAGCGGTGCATCGCGCTC
CGAACTCATCCGTCGGGCGATTCGCGCCACGTACGGCAGCGGAAGCAAAGAAGACCGGGTGGCCGCGCTGAAGCGAAGTG
CCGGCAGCTGGCGTAGACGTGACTCCACTGGCGCCGAATACGTCGACGCGGTTCGCGGCGACCTCAACGAACGCCTGAGC
CGGCTCGGCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References