Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3452965..3453575 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS16880 Protein ID WP_083131547.1
Coordinates 3452965..3453357 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS16885 Protein ID WP_083131548.1
Coordinates 3453354..3453575 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS16860 3448252..3449496 + 1245 WP_083131543.1 cytochrome P450 -
G6N47_RS16865 3449459..3450307 - 849 WP_083131544.1 NAD-dependent protein deacetylase -
G6N47_RS16870 3450318..3450860 - 543 WP_083131545.1 cysteine hydrolase -
G6N47_RS16875 3450919..3452961 + 2043 WP_083131546.1 NAD(+) synthase -
G6N47_RS16880 3452965..3453357 - 393 WP_083131547.1 PIN domain-containing protein Toxin
G6N47_RS16885 3453354..3453575 - 222 WP_083131548.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS16890 3453703..3454311 - 609 WP_083131549.1 isoprenylcysteine carboxylmethyltransferase family protein -
G6N47_RS16895 3454308..3455135 - 828 WP_083131550.1 enoyl-CoA hydratase/isomerase family protein -
G6N47_RS16900 3455150..3456001 - 852 WP_083131551.1 ribokinase -
G6N47_RS16905 3456087..3457334 + 1248 WP_083131552.1 glutamate-5-semialdehyde dehydrogenase -
G6N47_RS16910 3457345..3458220 + 876 WP_083131553.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14645.55 Da        Isoelectric Point: 7.0619

>T36338 WP_083131547.1 NZ_AP022606:c3453357-3452965 [Mycobacterium branderi]
MTFVDTSFWAALGNATDARHDIAKELWASRPPVVVTSNHVLGETWTLLNRRCGHRAAAAAAAIRYSAIVRVEHITAELEE
QAWLWLARHDEREYSFVDATSFALMRKKKVHNAYAFDGDFSAAGFVELRP

Download         Length: 393 bp

>T36338 NZ_AP022606:c3453357-3452965 [Mycobacterium branderi]
ATGACCTTCGTTGATACGTCCTTCTGGGCTGCGCTCGGCAACGCGACGGACGCTCGACATGACATTGCCAAGGAACTTTG
GGCCAGCAGGCCTCCCGTCGTGGTGACATCGAATCATGTCCTGGGCGAAACCTGGACGCTGCTCAACCGGCGTTGCGGTC
ATCGGGCCGCAGCGGCCGCGGCCGCGATCCGGTACAGCGCCATCGTTCGGGTCGAGCACATCACGGCAGAACTGGAGGAG
CAAGCCTGGTTATGGCTGGCTCGACACGACGAGCGAGAGTACTCGTTCGTCGACGCGACGAGTTTCGCGCTGATGCGTAA
GAAAAAGGTCCACAATGCCTACGCATTCGACGGTGACTTCAGCGCAGCCGGATTCGTCGAGCTGAGACCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8348.36 Da        Isoelectric Point: 5.8560

>AT36338 WP_083131548.1 NZ_AP022606:c3453575-3453354 [Mycobacterium branderi]
MKRLQIYIEEDVDQALGVEARRRRKSKAALIREYVADRLRKPHRDPVDDFIGSFDSGADLSASVDEAVYGPRE

Download         Length: 222 bp

>AT36338 NZ_AP022606:c3453575-3453354 [Mycobacterium branderi]
ATGAAGCGGCTGCAGATATATATCGAAGAGGACGTTGACCAGGCGCTCGGAGTTGAAGCCCGGCGGCGGCGCAAGTCGAA
GGCAGCTCTCATCCGGGAGTACGTGGCCGATCGCCTTCGCAAGCCCCACCGAGACCCAGTCGACGACTTCATCGGATCAT
TCGACAGCGGTGCCGACTTGTCCGCATCAGTTGATGAGGCCGTCTACGGGCCGCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References