Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2812330..2812898 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS14455 Protein ID WP_083134392.1
Coordinates 2812330..2812704 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS14460 Protein ID WP_083134391.1
Coordinates 2812701..2812898 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS14435 2807893..2809524 + 1632 WP_083134395.1 L-glutamate gamma-semialdehyde dehydrogenase -
G6N47_RS14440 2809580..2810587 + 1008 WP_083134407.1 proline dehydrogenase family protein -
G6N47_RS14445 2810597..2810833 - 237 WP_083134394.1 hypothetical protein -
G6N47_RS14450 2810830..2812281 - 1452 WP_083134393.1 MFS transporter -
G6N47_RS14455 2812330..2812704 - 375 WP_083134392.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N47_RS14460 2812701..2812898 - 198 WP_083134391.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N47_RS14465 2813023..2813856 + 834 WP_083134390.1 alpha/beta hydrolase -
G6N47_RS14470 2813976..2814575 - 600 WP_083134389.1 TetR/AcrR family transcriptional regulator -
G6N47_RS14475 2814620..2815450 + 831 WP_083134388.1 alpha/beta hydrolase -
G6N47_RS14480 2815627..2817039 + 1413 WP_083134387.1 wax ester/triacylglycerol synthase family O-acyltransferase -
G6N47_RS14485 2817094..2817423 + 330 WP_083134386.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13558.77 Da        Isoelectric Point: 7.1166

>T36337 WP_083134392.1 NZ_AP022606:c2812704-2812330 [Mycobacterium branderi]
VILVDTSVWIDHLHHTDPRLVALLNADEVGCHPYVIDELALGSIKQRAIVIELLGSLHRFPVLTHAEVMTLVDRRRLFGR
GLSAVDAHLLGSVSLVGGARLWTRDKRLIAVCRDTGVPSLAESG

Download         Length: 375 bp

>T36337 NZ_AP022606:c2812704-2812330 [Mycobacterium branderi]
GTGATCCTCGTCGACACCTCGGTGTGGATCGATCATCTCCACCACACGGACCCCCGATTGGTCGCTCTCCTGAATGCAGA
CGAAGTCGGATGTCACCCATACGTGATCGACGAATTGGCGCTTGGATCGATCAAACAGCGCGCCATAGTCATTGAACTAC
TCGGCAGTTTGCATCGATTTCCCGTTCTCACGCACGCCGAGGTGATGACGCTCGTCGACCGCCGCAGGCTCTTCGGGCGT
GGCCTGAGCGCGGTGGACGCTCACCTCCTCGGGTCGGTGTCGCTCGTCGGCGGGGCGCGGCTGTGGACCCGCGACAAGCG
GCTGATCGCTGTGTGCCGCGACACCGGAGTGCCTTCTCTCGCCGAGTCCGGATAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6878.87 Da        Isoelectric Point: 11.2729

>AT36337 WP_083134391.1 NZ_AP022606:c2812898-2812701 [Mycobacterium branderi]
MRTTVTIDDELLARASELTGITEKSVLLRNGLTTLIRVESARRLAALGGSEKEAAAAPRRRGSAG

Download         Length: 198 bp

>AT36337 NZ_AP022606:c2812898-2812701 [Mycobacterium branderi]
ATGAGGACGACGGTGACGATCGACGACGAACTCTTGGCCCGCGCGAGCGAGCTGACGGGAATCACCGAGAAGTCGGTGCT
GCTGCGCAACGGGTTGACGACCCTGATACGTGTCGAAAGCGCCCGTCGACTGGCCGCTCTCGGAGGGTCGGAGAAGGAGG
CCGCTGCGGCGCCCCGGCGACGGGGCTCCGCCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References