Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1933548..1934191 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS09960 Protein ID WP_083131112.1
Coordinates 1933548..1933970 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS09965 Protein ID WP_083131111.1
Coordinates 1933967..1934191 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS09940 1928620..1929462 + 843 WP_083131116.1 sulfurtransferase -
G6N47_RS09945 1929482..1930555 + 1074 WP_083131115.1 LacI family DNA-binding transcriptional regulator -
G6N47_RS09950 1930563..1931168 - 606 WP_163659790.1 cholesterol catabolism transcriptional regulator KstR -
G6N47_RS09955 1931408..1933489 + 2082 WP_083131113.1 acyl-CoA dehydrogenase -
G6N47_RS09960 1933548..1933970 - 423 WP_083131112.1 PIN domain-containing protein Toxin
G6N47_RS09965 1933967..1934191 - 225 WP_083131111.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N47_RS09970 1934500..1935027 - 528 WP_179966440.1 hypothetical protein -
G6N47_RS09975 1935053..1936132 - 1080 WP_083131110.1 ferredoxin--NADP reductase -
G6N47_RS09980 1936229..1937416 + 1188 WP_083131109.1 flavin-dependent monooxygenase -
G6N47_RS09985 1937413..1938279 + 867 WP_083131108.1 alpha/beta fold hydrolase -
G6N47_RS09990 1938279..1939184 + 906 WP_083131107.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-37)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15477.50 Da        Isoelectric Point: 4.6182

>T36334 WP_083131112.1 NZ_AP022606:c1933970-1933548 [Mycobacterium branderi]
VIVLDTGGLYALLDSSDSYHHDAHRAIDGYDGPLLLSPLILAETDYLVSKRLGRRAESAFLADVTERVYRLVGFDDEDLE
SAVNLVNTYADMNIGIADASVAVIARRYRTVDLLSVDRHFRAIGPLWGEAFSLLPLDARK

Download         Length: 423 bp

>T36334 NZ_AP022606:c1933970-1933548 [Mycobacterium branderi]
GTGATCGTCTTGGACACCGGCGGCCTCTACGCGCTGCTGGACTCGTCCGACAGCTACCACCACGACGCGCATCGGGCGAT
TGACGGCTACGACGGCCCTCTATTGCTGTCGCCGTTGATCCTGGCGGAGACCGATTACCTCGTGTCTAAACGACTAGGGC
GGCGGGCCGAGTCTGCGTTCTTAGCTGACGTGACCGAAAGGGTCTATCGTCTGGTGGGTTTCGACGACGAGGACCTCGAG
TCAGCAGTGAACCTGGTGAACACGTATGCCGACATGAATATTGGGATAGCGGACGCCTCGGTAGCAGTGATCGCTCGGCG
TTACCGGACCGTCGATCTACTCAGCGTCGATCGACACTTTCGCGCGATTGGACCGTTATGGGGGGAAGCGTTCAGTCTGC
TTCCCCTCGACGCTCGAAAGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8334.31 Da        Isoelectric Point: 7.0158

>AT36334 WP_083131111.1 NZ_AP022606:c1934191-1933967 [Mycobacterium branderi]
VKKTTIYLDDATDSRLAEMSRRRGRSRAALIRDAVERMIVDDDRPPRRPRPLGASGHPDTSERVDEVLAEGFGE

Download         Length: 225 bp

>AT36334 NZ_AP022606:c1934191-1933967 [Mycobacterium branderi]
GTGAAGAAGACGACGATCTATCTGGACGACGCCACCGACAGTCGGCTCGCCGAAATGTCGCGGCGACGTGGCCGTTCGCG
GGCTGCCCTGATCCGTGACGCGGTCGAGCGCATGATCGTCGACGACGATCGGCCGCCCCGCCGTCCGCGCCCCCTGGGCG
CGAGCGGCCACCCAGACACCTCCGAGCGGGTAGACGAGGTTCTCGCGGAGGGATTCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References