Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 685950..686490 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N47_RS03720 Protein ID WP_083130242.1
Coordinates 685950..686258 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N47_RS03725 Protein ID WP_083130519.1
Coordinates 686245..686490 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS03700 681573..683866 - 2294 Protein_736 GH92 family glycosyl hydrolase -
G6N47_RS03705 684099..684485 - 387 WP_139799330.1 hypothetical protein -
G6N47_RS03710 684762..685427 + 666 WP_139799331.1 helix-turn-helix domain-containing protein -
G6N47_RS03715 685420..685923 + 504 WP_139799332.1 hypothetical protein -
G6N47_RS03720 685950..686258 - 309 WP_083130242.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N47_RS03725 686245..686490 - 246 WP_083130519.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N47_RS03730 686551..686964 - 414 WP_083130243.1 DUF86 domain-containing protein -
G6N47_RS03735 686954..687406 - 453 WP_197945495.1 nucleotidyltransferase domain-containing protein -
G6N47_RS03740 687418..687912 + 495 WP_083130520.1 thiol peroxidase -
G6N47_RS03745 687916..688765 - 850 Protein_745 hypothetical protein -
G6N47_RS03750 688828..691194 + 2367 WP_083130245.1 flippase-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11196.90 Da        Isoelectric Point: 11.6554

>T36331 WP_083130242.1 NZ_AP022606:c686258-685950 [Mycobacterium branderi]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVASLTRTRRGLVSELELTAAEDGVPSDCVVNFDNLHTLPRSAFRRR
ITRLSAARLHQVCRTLRASTGC

Download         Length: 309 bp

>T36331 NZ_AP022606:c686258-685950 [Mycobacterium branderi]
ATGCGGCGCGGTGAACTCTGGTTCGCCGCCACGCCCGGCGGTGATCGCCCGGTGCTCGTCCTCACCAGGGATCCCGTCGC
CGACCGGATCGGCGCGGTCGTCGTCGCCTCACTGACCCGAACCCGCAGAGGACTGGTGTCGGAACTGGAACTGACGGCTG
CTGAAGATGGCGTGCCAAGCGACTGCGTCGTCAACTTCGACAACCTTCATACGTTGCCGCGTAGCGCATTTCGCCGCAGG
ATCACCCGGTTGTCTGCGGCACGGCTCCACCAAGTGTGCCGCACATTGCGCGCAAGCACTGGCTGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9219.12 Da        Isoelectric Point: 4.1086

>AT36331 WP_083130519.1 NZ_AP022606:c686490-686245 [Mycobacterium branderi]
MISFRVDDADAAEIDQWARRLHVERSELIRDALRRHLAQLAADEDVRAYAEQPVTGEEMALAEVAEWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT36331 NZ_AP022606:c686490-686245 [Mycobacterium branderi]
ATGATCAGCTTTCGCGTGGACGACGCGGACGCCGCCGAAATAGACCAATGGGCGCGGCGGCTGCACGTCGAGCGGTCCGA
GCTCATTCGCGACGCGCTGCGACGCCACTTGGCTCAGCTCGCGGCCGACGAGGACGTGCGCGCATACGCCGAGCAGCCCG
TCACGGGCGAGGAAATGGCGCTCGCTGAGGTCGCCGAGTGGGGCCCCGCGGAGGACTGGGCTGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References