Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 660595..661187 Replicon chromosome
Accession NZ_AP022606
Organism Mycobacterium branderi strain JCM 12687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N47_RS03610 Protein ID WP_083130224.1
Coordinates 660595..660993 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N47_RS03615 Protein ID WP_083130225.1
Coordinates 660990..661187 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N47_RS03590 656245..656952 + 708 WP_083130221.1 TVP38/TMEM64 family protein -
G6N47_RS03595 657216..657554 - 339 WP_139799327.1 hypothetical protein -
G6N47_RS03600 657542..657721 - 180 WP_083130223.1 hypothetical protein -
G6N47_RS03605 658030..660561 + 2532 WP_083130515.1 SEC-C domain-containing protein -
G6N47_RS03610 660595..660993 - 399 WP_083130224.1 PIN domain nuclease Toxin
G6N47_RS03615 660990..661187 - 198 WP_083130225.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N47_RS03620 661516..661950 + 435 WP_083130226.1 hypothetical protein -
G6N47_RS03625 661966..663396 - 1431 WP_083130227.1 serine hydrolase -
G6N47_RS03630 663393..665069 - 1677 WP_083130228.1 patatin-like phospholipase family protein -
G6N47_RS03635 665075..665479 - 405 WP_083130229.1 PIN domain-containing protein -
G6N47_RS03640 665483..665725 - 243 WP_083130230.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 653759..685923 32164


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14614.94 Da        Isoelectric Point: 5.1580

>T36330 WP_083130224.1 NZ_AP022606:c660993-660595 [Mycobacterium branderi]
VIVVDTSVWIDVLNDRPTPQAQRCVQLIESGEPVALTDVILTEILQGLRTDREATLVERHLRAFPILRLEDLDDFLLAAK
LYRAARCAGVTIRKTLDCLIAAPCVRTGAPLLHADQDFDHLASCTSLRIWGG

Download         Length: 399 bp

>T36330 NZ_AP022606:c660993-660595 [Mycobacterium branderi]
GTGATCGTCGTCGACACCAGCGTCTGGATCGACGTCCTGAATGACAGACCCACGCCGCAGGCTCAACGTTGCGTGCAGCT
GATTGAGTCGGGAGAACCCGTCGCACTCACTGATGTCATCCTGACCGAAATTCTGCAAGGGCTGCGCACGGATCGGGAGG
CGACGTTGGTGGAGCGCCATCTGCGCGCCTTCCCGATCCTTCGCCTGGAGGACCTCGATGATTTCCTACTGGCGGCCAAG
CTGTATCGCGCGGCGCGCTGTGCCGGTGTGACGATTCGCAAAACACTCGACTGTCTGATCGCCGCACCCTGTGTGCGTAC
CGGTGCCCCGCTGCTGCACGCCGACCAGGACTTCGACCACCTGGCCAGCTGTACATCGCTTCGAATCTGGGGTGGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7585.69 Da        Isoelectric Point: 11.5790

>AT36330 WP_083130225.1 NZ_AP022606:c661187-660990 [Mycobacterium branderi]
MRTNIEIDDDVLREAQRLLGTRTKRETVNLALRELVARHRQIGILDLRGKVHWEGDLGQSRRGRP

Download         Length: 198 bp

>AT36330 NZ_AP022606:c661187-660990 [Mycobacterium branderi]
ATGCGCACGAACATCGAGATCGACGACGACGTCTTGCGCGAGGCCCAGCGCCTGCTCGGGACGCGGACCAAGCGCGAGAC
GGTCAACCTTGCGCTGCGTGAACTCGTCGCCCGTCACCGCCAAATCGGTATTCTTGACCTGCGCGGGAAGGTGCACTGGG
AGGGTGACCTCGGCCAGAGTCGTCGCGGCCGGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References