Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 3518352..3519118 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag G6N07_RS17305 Protein ID WP_085192066.1
Coordinates 3518618..3519118 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag G6N07_RS17300 Protein ID WP_085192107.1
Coordinates 3518352..3518621 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS17265 3513651..3514346 + 696 WP_085192073.1 hypothetical protein -
G6N07_RS17270 3514363..3514920 + 558 WP_085192072.1 hypothetical protein -
G6N07_RS17275 3515106..3515330 + 225 WP_085192071.1 hypothetical protein -
G6N07_RS17280 3515340..3515891 - 552 WP_085192070.1 Fic family protein -
G6N07_RS17285 3515918..3516241 - 324 WP_085192069.1 helix-turn-helix domain-containing protein -
G6N07_RS17290 3516326..3516883 - 558 WP_085192068.1 hypothetical protein -
G6N07_RS17295 3516880..3517968 - 1089 WP_085192067.1 XRE family transcriptional regulator -
G6N07_RS17300 3518352..3518621 + 270 WP_085192107.1 DUF1778 domain-containing protein Antitoxin
G6N07_RS17305 3518618..3519118 + 501 WP_085192066.1 GNAT family N-acetyltransferase Toxin
G6N07_RS17310 3519248..3519472 - 225 WP_085192065.1 DUF4926 domain-containing protein -
G6N07_RS17315 3519885..3520325 + 441 WP_085192064.1 hypothetical protein -
G6N07_RS17320 3520369..3520593 - 225 WP_085192063.1 hypothetical protein -
G6N07_RS17325 3520824..3521057 + 234 WP_085192062.1 hypothetical protein -
G6N07_RS17330 3521054..3521389 + 336 WP_085192061.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N07_RS17335 3521546..3522070 + 525 WP_085192060.1 hypothetical protein -
G6N07_RS17340 3522100..3522696 + 597 WP_085192059.1 RES family NAD+ phosphorylase -
G6N07_RS17345 3522735..3522914 - 180 WP_085192058.1 hypothetical protein -
G6N07_RS17350 3523259..3523513 + 255 WP_133055557.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-142)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 17923.40 Da        Isoelectric Point: 6.6397

>T36328 WP_085192066.1 NZ_AP022605:3518618-3519118 [Mycolicibacterium doricum]
VSGYSAPRPISEHDLVAEFDSGEPSLDDYLRGRALANHVEGASRCFVTCRDGRVVGFYALASAAVERAGTSGRVRRNMPN
PVPVILLSRLAIDRKEQGQGLGAALLRDAITRAVAAAEIIGVRALLVHEQARAFYAHFDFEPSPTDPLHLLLLIKDARAL
LDPPSD

Download         Length: 501 bp

>T36328 NZ_AP022605:3518618-3519118 [Mycolicibacterium doricum]
GTGAGCGGCTACAGCGCGCCCAGGCCGATCAGCGAGCACGATCTGGTCGCCGAGTTCGACAGCGGCGAGCCCAGCCTGGA
CGACTACCTGCGGGGACGAGCCCTGGCCAACCACGTCGAAGGTGCCTCCCGGTGCTTCGTGACGTGCCGCGACGGCCGCG
TCGTCGGGTTCTACGCGCTGGCCTCGGCTGCTGTGGAGCGCGCCGGCACGTCAGGACGGGTGCGGCGCAACATGCCCAAT
CCAGTGCCGGTGATCCTGTTGTCGCGGCTGGCGATCGACCGCAAGGAACAGGGCCAGGGCCTCGGAGCTGCGCTGCTACG
CGATGCGATCACCCGCGCGGTGGCCGCCGCGGAGATCATCGGTGTGCGGGCACTGCTGGTGCACGAGCAGGCACGGGCGT
TCTACGCCCACTTCGACTTCGAGCCATCACCGACCGACCCGCTGCACCTGCTGCTGCTGATCAAAGACGCCCGCGCTCTA
CTCGATCCACCGTCCGATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9974.35 Da        Isoelectric Point: 5.1007

>AT36328 WP_085192107.1 NZ_AP022605:3518352-3518621 [Mycolicibacterium doricum]
MATKTERFAVRLTAEQDALIRRAAEVEGTDLTNFTVTATLAHARDVLADRRLFMLDAPAWSEFVSVLDRPVSHKPRLGTL
FAEPSIFDE

Download         Length: 270 bp

>AT36328 NZ_AP022605:3518352-3518621 [Mycolicibacterium doricum]
ATGGCTACGAAGACGGAGCGGTTCGCTGTGCGCCTGACGGCTGAGCAAGACGCGCTGATTCGTCGTGCCGCCGAAGTGGA
GGGGACCGACCTCACCAACTTCACGGTGACCGCGACGCTGGCTCATGCCCGCGACGTACTTGCCGATCGCCGGCTGTTCA
TGCTCGACGCGCCGGCCTGGTCGGAGTTCGTGTCGGTGCTGGACCGGCCGGTGTCGCACAAACCGCGGCTGGGGACGCTG
TTCGCGGAGCCCTCGATCTTCGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References