Detailed information of TA system TA036327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3431316..3432295
• Replicon: chromosome
• Accession: NZ_AP022605
• Organism: Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N07_RS16800
• Protein ID: WP_085191864.1
• Coordinates: 3431316..3431894 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G6N07_RS16805
• Protein ID: WP_085191866.1
• Coordinates: 3431891..3432295 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N07_RS16775	3427000..3427536	-	537	WP_085188560.1	copper chaperone PCu(A)C	-
G6N07_RS16780	3427539..3428447	-	909	WP_085188212.1	PepSY domain-containing protein	-
G6N07_RS16785	3428759..3430376	+	1618	Protein_3290	MarR family transcriptional regulator	-
G6N07_RS16790	3430461..3430853	-	393	WP_085191862.1	hypothetical protein	-
G6N07_RS16795	3430963..3431100	-	138	WP_163784237.1	hypothetical protein	-
G6N07_RS16800	3431316..3431894	-	579	WP_085191864.1	zeta toxin family protein	Toxin
G6N07_RS16805	3431891..3432295	-	405	WP_085191866.1	hypothetical protein	Antitoxin
G6N07_RS16810	3432458..3433132	+	675	WP_085191868.1	phosphate ABC transporter ATP-binding protein	-
G6N07_RS16815	3433135..3433929	+	795	WP_085191946.1	iron export ABC transporter permease subunit FetB	-
G6N07_RS16825	3434550..3436106	+	1557	WP_085191870.1	NCS1 family nucleobase:cation symporter-1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-104)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21384.27 Da
• Isoelectric Point: 9.6499

>T36327 WP_085191864.1 NZ_AP022605:c3431894-3431316 [Mycolicibacterium doricum]
MNRLDLVVGPNGAGKSTFVTFTLAPLLPRSVFVNADEIARQRWPDDVETHAYEAAGIAAATRSTLVAQRRSFIAETVFSH
PSKLDLITAAHAAQYTVVLHVFMVTEDLSVERVRHRVIAGGHSVPEDKIRGRHRRLWDLVERAMTLSDTATVYDNSRREG
PRIVAQFVGRDIVGAPSWPEWTPSTFASRWPA

Nucleotide

• Length: 579 bp

>T36327 NZ_AP022605:c3431894-3431316 [Mycolicibacterium doricum]
ATGAACCGACTCGATCTCGTCGTCGGCCCCAACGGCGCCGGGAAGTCAACCTTCGTCACCTTCACGCTCGCGCCGCTGCT
CCCCCGCAGCGTCTTTGTTAACGCCGACGAGATCGCCCGCCAACGTTGGCCCGACGACGTGGAGACACATGCCTATGAGG
CCGCAGGAATCGCCGCGGCGACCCGGTCCACACTCGTCGCACAACGCCGCTCCTTCATCGCGGAGACAGTGTTCTCACAT
CCCTCGAAGCTCGACCTCATCACCGCGGCCCACGCCGCCCAGTACACCGTCGTGCTCCACGTATTTATGGTTACGGAGGA
CCTGTCCGTCGAGCGTGTGCGCCATCGAGTGATCGCCGGCGGCCACAGTGTCCCCGAAGACAAAATCCGGGGCCGGCACC
GTCGGCTCTGGGACCTCGTGGAGCGCGCAATGACGCTGTCCGACACCGCGACGGTCTACGACAACAGTCGACGCGAGGGT
CCTCGAATCGTCGCCCAGTTCGTCGGTCGCGATATCGTCGGTGCACCGTCGTGGCCGGAGTGGACGCCATCGACGTTTGC
GTCTCGCTGGCCCGCGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14048.45 Da
• Isoelectric Point: 5.5239

>AT36327 WP_085191866.1 NZ_AP022605:c3432295-3431891 [Mycolicibacterium doricum]
MGEVADRVTRVAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSQQTLARRRVEAALAGDADLNTLSAEEGVVFNAEI
AAAVEEHLAGSHYGDRLAAHGITTVSMNSAGQLVEHRPDGTSVILDESPAARHG

Nucleotide

• Length: 405 bp

>AT36327 NZ_AP022605:c3432295-3431891 [Mycolicibacterium doricum]
ATGGGTGAGGTTGCCGATCGTGTCACCCGTGTCGCCGCAGACCTGATCGACAGCGCAGCTGCCGAGGGGGCACGCCAAAG
CCGCTCCGCCAAGCAGCAGCTGGACCACTGGGCGCGAGTGGGCCGGGCCGTGTCAAGCCAGCAGACGCTCGCCCGTCGCC
GCGTCGAGGCCGCACTGGCGGGCGATGCAGACCTCAACACGTTGAGCGCGGAAGAAGGTGTCGTCTTCAACGCCGAGATC
GCCGCGGCGGTCGAGGAGCACCTGGCCGGTAGCCACTACGGGGACCGACTCGCGGCCCATGGCATCACCACCGTCTCCAT
GAACAGCGCCGGCCAACTCGTCGAGCACCGCCCGGACGGTACCTCCGTGATCCTCGACGAGAGCCCGGCCGCTCGTCACG
GATGA