Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3156417..3157076 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N07_RS15380 Protein ID WP_085192621.1
Coordinates 3156417..3156854 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N07_RS15385 Protein ID WP_085192620.1
Coordinates 3156858..3157076 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS15350 3151736..3152155 - 420 WP_085192737.1 hypothetical protein -
G6N07_RS15355 3152250..3152696 + 447 WP_085192743.1 cupin domain-containing protein -
G6N07_RS15360 3152686..3153411 - 726 WP_085192736.1 3-keto-5-aminohexanoate cleavage protein -
G6N07_RS15365 3153562..3154995 - 1434 WP_085192735.1 aldehyde dehydrogenase family protein -
G6N07_RS15370 3155298..3155834 - 537 WP_163784224.1 transposase -
G6N07_RS15375 3155783..3156046 - 264 WP_163784226.1 helix-turn-helix domain-containing protein -
G6N07_RS15380 3156417..3156854 - 438 WP_085192621.1 SRPBCC family protein Toxin
G6N07_RS15385 3156858..3157076 - 219 WP_085192620.1 antitoxin Antitoxin
G6N07_RS15390 3157086..3159509 - 2424 WP_085192619.1 HAD-IC family P-type ATPase -
G6N07_RS15395 3159634..3161235 - 1602 WP_085192618.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15924.61 Da        Isoelectric Point: 9.8765

>T36326 WP_085192621.1 NZ_AP022605:c3156854-3156417 [Mycolicibacterium doricum]
MAKLSVSVDVPLPPEKAWECASDLSRYKEWLSMHRAWRSKLPETLDKGARIDSIVEVMGMPNRIHWTIVHYKPPQAMTLN
GDGRGGVKVKLMAKVKPSDEGSTVTFDIHLGGPALFGPIGMLVAGALKSDIRESLDRFKAVFAPA

Download         Length: 438 bp

>T36326 NZ_AP022605:c3156854-3156417 [Mycolicibacterium doricum]
ATGGCGAAGCTGTCCGTCTCCGTGGACGTCCCCCTACCGCCGGAGAAGGCGTGGGAGTGCGCCTCTGACCTGTCGCGATA
CAAGGAATGGCTGTCTATGCACCGGGCGTGGCGGTCGAAGCTACCCGAGACGCTGGACAAGGGCGCCCGCATCGACTCGA
TCGTCGAGGTGATGGGCATGCCGAACCGGATCCACTGGACCATCGTGCACTACAAGCCCCCGCAGGCGATGACGCTGAAC
GGCGACGGCAGGGGTGGGGTGAAGGTCAAGCTGATGGCCAAGGTGAAACCGTCCGATGAGGGGTCGACCGTCACGTTCGA
CATCCACCTCGGTGGCCCCGCGCTGTTCGGGCCGATCGGCATGCTCGTCGCCGGTGCGCTCAAGAGCGACATCCGCGAGT
CACTCGACCGGTTCAAGGCGGTCTTCGCCCCGGCCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7846.81 Da        Isoelectric Point: 9.5425

>AT36326 WP_085192620.1 NZ_AP022605:c3157076-3156858 [Mycolicibacterium doricum]
MAFLDKVKNWVSKNPDKAGSAIEKAGDLFDQKTKGKYADKVNKAQGAAQNYVDKSDPQEQPPVSPPNPPLHP

Download         Length: 219 bp

>AT36326 NZ_AP022605:c3157076-3156858 [Mycolicibacterium doricum]
ATGGCATTCCTCGACAAGGTGAAGAACTGGGTGTCGAAGAACCCCGACAAGGCCGGCAGCGCGATAGAGAAGGCCGGCGA
CCTCTTCGACCAGAAGACCAAGGGCAAGTACGCCGACAAGGTGAACAAGGCCCAGGGCGCGGCGCAGAACTACGTCGACA
AGAGCGACCCTCAGGAGCAGCCGCCGGTCAGCCCACCGAATCCGCCTCTGCACCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References