Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2884257..2884783 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag G6N07_RS13995 Protein ID WP_085189275.1
Coordinates 2884481..2884783 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag G6N07_RS13990 Protein ID WP_085189274.1
Coordinates 2884257..2884484 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS13960 2880053..2881000 + 948 WP_085189266.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
G6N07_RS13965 2881438..2881707 + 270 WP_085189268.1 metal-sensitive transcriptional regulator -
G6N07_RS13970 2881729..2882130 + 402 WP_085189331.1 DUF302 domain-containing protein -
G6N07_RS13980 2882200..2883612 - 1413 WP_085189270.1 acyl-CoA synthetase -
G6N07_RS13985 2883654..2884193 + 540 WP_085189272.1 NUDIX hydrolase -
G6N07_RS13990 2884257..2884484 + 228 WP_085189274.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N07_RS13995 2884481..2884783 + 303 WP_085189275.1 toxin Toxin
G6N07_RS14000 2884888..2885875 - 988 Protein_2750 hypothetical protein -
G6N07_RS14005 2885941..2887053 - 1113 WP_085189277.1 succinyldiaminopimelate transaminase -
G6N07_RS14010 2887082..2887405 - 324 WP_085189279.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10377.03 Da        Isoelectric Point: 4.5605

>T36325 WP_085189275.1 NZ_AP022605:2884481-2884783 [Mycolicibacterium doricum]
VITPGDIAPRRDTGHEAYVVILSNSIHLAADSGRLISCAFVPGRIPDAAMAMVVAVQQPEGAVLPELVQWLPTAALDEPI
GNIGAQALRQTAALITALVT

Download         Length: 303 bp

>T36325 NZ_AP022605:2884481-2884783 [Mycolicibacterium doricum]
GTGATCACACCCGGTGACATCGCGCCACGGCGGGACACCGGACACGAGGCCTATGTGGTCATCCTCTCGAACTCCATCCA
CCTCGCCGCTGACTCCGGCAGGCTCATCTCTTGCGCCTTCGTTCCCGGCCGAATCCCCGACGCCGCTATGGCGATGGTCG
TAGCAGTCCAGCAGCCCGAAGGCGCGGTGCTGCCAGAACTCGTCCAGTGGCTGCCCACCGCCGCGCTCGACGAACCCATC
GGCAACATCGGCGCACAGGCGCTGCGCCAGACCGCAGCGCTGATCACTGCACTGGTCACCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8177.22 Da        Isoelectric Point: 5.5127

>AT36325 WP_085189274.1 NZ_AP022605:2884257-2884484 [Mycolicibacterium doricum]
MVKNKVSVTVDTDVLAAADADATAVGMNRSELIEQALRHEHLRLALQNYTAHTVPALNIDDYAAKIYQANRAADL

Download         Length: 228 bp

>AT36325 NZ_AP022605:2884257-2884484 [Mycolicibacterium doricum]
ATGGTCAAAAATAAGGTGTCCGTCACCGTCGATACCGATGTGCTCGCCGCCGCAGACGCCGACGCCACGGCTGTCGGCAT
GAACCGGTCCGAACTCATCGAGCAGGCGCTGCGGCACGAACATCTGCGCCTCGCCCTGCAGAACTACACCGCGCACACCG
TGCCGGCGCTCAACATCGACGACTACGCCGCCAAGATCTACCAGGCCAACAGGGCTGCCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References