Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1969980..1970515 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N07_RS09670 Protein ID WP_085192648.1
Coordinates 1969980..1970312 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N07_RS09675 Protein ID WP_085192647.1
Coordinates 1970309..1970515 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS09655 1966183..1969023 + 2841 WP_163784164.1 AAA family ATPase -
G6N07_RS09660 1969188..1969586 - 399 WP_085192650.1 type II toxin-antitoxin system VapC family toxin -
G6N07_RS09665 1969607..1969843 - 237 WP_085192649.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6N07_RS09670 1969980..1970312 - 333 WP_085192648.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N07_RS09675 1970309..1970515 - 207 WP_085192647.1 antitoxin MazE family protein Antitoxin
G6N07_RS09680 1970692..1971003 - 312 WP_085192646.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N07_RS09685 1970993..1971226 - 234 WP_085192645.1 hypothetical protein -
G6N07_RS09690 1971707..1973106 - 1400 Protein_1914 IS1380 family transposase -
G6N07_RS19890 1973714..1973812 + 99 WP_197913023.1 DUF2254 domain-containing protein -
G6N07_RS19895 1973853..1974215 + 363 WP_197913024.1 hypothetical protein -
G6N07_RS09700 1974260..1975141 - 882 WP_197913038.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1883945..1973106 89161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11857.65 Da        Isoelectric Point: 7.2041

>T36324 WP_085192648.1 NZ_AP022605:c1970312-1969980 [Mycolicibacterium doricum]
VNRGEIWTVAGSVYATKPRPAVIVQDDLFDATTSVTVAPISSALLDAPLMRIRIAGGDGRLSGLDHDSDVMIDKLTTVRR
SNVHARVGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

>T36324 NZ_AP022605:c1970312-1969980 [Mycolicibacterium doricum]
GTGAACCGAGGAGAGATCTGGACCGTAGCGGGGAGTGTCTACGCGACAAAACCGCGTCCCGCGGTGATTGTCCAGGATGA
TCTGTTCGATGCCACCACGTCGGTGACGGTTGCGCCGATCAGCAGCGCATTACTGGACGCTCCGCTAATGCGCATTCGGA
TAGCCGGCGGAGACGGTCGGTTATCCGGACTCGACCACGACAGTGACGTGATGATCGACAAGCTCACAACTGTCAGGAGA
TCTAACGTCCACGCGCGAGTCGGTCGACTGACTGCAGAACAAGTCGTCGAAGTGGAGCGAGCGATGATGGCATTTCTCGG
CCTTGCACGGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7975.83 Da        Isoelectric Point: 5.1425

>AT36324 WP_085192647.1 NZ_AP022605:c1970515-1970309 [Mycolicibacterium doricum]
MGVRERVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQSSLVARADESSDDQEFIEAVSTPWDKE

Download         Length: 207 bp

>AT36324 NZ_AP022605:c1970515-1970309 [Mycolicibacterium doricum]
ATGGGGGTGAGAGAAAGGGTCGGCGAGTACCGACGGCGCATGCGGGAGCGGGGCCTGCGCCCGCTGCAGGTCTGGGTACC
TGACGTGCGCACCGAGAGTTTTGCCGCCGAAGCTCATCGCCAATCCTCGCTGGTGGCACGGGCGGACGAAAGCAGCGATG
ACCAGGAATTCATCGAAGCTGTCTCGACGCCATGGGACAAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References