Detailed information of TA system TA036323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1920631..1921259
• Replicon: chromosome
• Accession: NZ_AP022605
• Organism: Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N07_RS09520
• Protein ID: WP_085192573.1
• Coordinates: 1920631..1921041 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1X1SYP9
• Locus tag: G6N07_RS09525
• Protein ID: WP_064876252.1
• Coordinates: 1921032..1921259 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N07_RS09490	1915978..1917591	-	1614	WP_099050156.1	apolipoprotein N-acyltransferase	-
G6N07_RS09495	1917768..1918409	-	642	WP_085188858.1	TlpA family protein disulfide reductase	-
G6N07_RS09500	1918797..1919195	+	399	WP_179959971.1	metalloregulator ArsR/SmtB family transcription factor	-
G6N07_RS09505	1919217..1919594	+	378	WP_110807719.1	signal peptidase II	-
G6N07_RS09510	1919591..1920193	+	603	WP_064875957.1	cadmium resistance transporter	-
G6N07_RS09515	1920261..1920389	+	129	Protein_1879	TlpA family protein disulfide reductase	-
G6N07_RS09520	1920631..1921041	-	411	WP_085192573.1	PIN domain nuclease	Toxin
G6N07_RS09525	1921032..1921259	-	228	WP_064876252.1	hypothetical protein	Antitoxin
G6N07_RS09530	1921893..1923620	+	1728	WP_082947967.1	O-acetyl-ADP-ribose deacetylase	-
G6N07_RS09535	1923884..1924862	+	979	Protein_1883	hypothetical protein	-
G6N07_RS09540	1925477..1925947	-	471	WP_085192470.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1883945..1973106	89161

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (17-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14815.99 Da
• Isoelectric Point: 4.8950

>T36323 WP_085192573.1 NZ_AP022605:c1921041-1920631 [Mycolicibacterium doricum]
VAVTNWIIDKSAYTRLSASRDAAAWIERIERGLVRISTVTRLEIGYSFRTGQQAREETASPPLSLMPVEYLTPAAEDRAV
AVQMLLADRGQHRAPAIPDLLVAATAELGGLTVLALDKDFDLIAQVTGQPVESLRM

Nucleotide

• Length: 411 bp

>T36323 NZ_AP022605:c1921041-1920631 [Mycolicibacterium doricum]
GTGGCGGTGACTAATTGGATCATCGACAAATCCGCCTACACACGGCTATCGGCGTCGCGCGACGCCGCGGCCTGGATCGA
ACGCATCGAACGCGGCCTCGTCCGCATCAGCACCGTCACCCGACTAGAAATCGGATACTCGTTCCGCACCGGCCAACAGG
CGCGCGAGGAGACAGCATCCCCTCCCCTGAGCCTGATGCCGGTCGAGTACTTGACACCGGCCGCTGAGGACCGCGCCGTC
GCGGTGCAAATGCTGCTGGCCGATCGCGGCCAGCACCGCGCCCCCGCCATTCCTGATCTTCTCGTCGCCGCGACCGCAGA
ACTCGGTGGGCTGACCGTGCTGGCGCTGGACAAGGACTTCGATCTCATCGCCCAGGTCACCGGTCAGCCCGTTGAGAGCC
TGCGGATGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8129.04 Da
• Isoelectric Point: 4.7420

>AT36323 WP_064876252.1 NZ_AP022605:c1921259-1921032 [Mycolicibacterium doricum]
VSDVLIRGLSEGAVARIDADAAARGLSRQEYLRQRFEREGTVGATQRSLTLADLRRAEAAAADLDDPGVMDTAWR

Nucleotide

• Length: 228 bp

>AT36323 NZ_AP022605:c1921259-1921032 [Mycolicibacterium doricum]
GTGAGCGACGTGCTGATCCGAGGATTGTCCGAGGGGGCGGTGGCGCGCATCGACGCCGACGCGGCCGCGCGCGGCCTGTC
CCGCCAAGAGTATCTGCGTCAGCGGTTCGAGCGCGAAGGGACAGTGGGCGCGACCCAGCGCTCGCTGACGCTGGCCGACC
TGCGCCGCGCTGAGGCCGCCGCCGCCGACCTCGACGATCCCGGCGTGATGGACACAGCGTGGCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X1SYP9