Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1156677..1157296 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N07_RS05750 Protein ID WP_085189703.1
Coordinates 1156677..1157087 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N07_RS05755 Protein ID WP_179959952.1
Coordinates 1157078..1157296 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS05725 1152656..1152955 + 300 WP_163784120.1 Rieske (2Fe-2S) protein -
G6N07_RS05730 1152952..1154211 + 1260 WP_133055525.1 ATP-grasp domain-containing protein -
G6N07_RS05735 1154757..1155149 - 393 WP_085189699.1 transposase -
G6N07_RS05740 1155156..1155449 - 294 WP_133055526.1 hypothetical protein -
G6N07_RS05745 1155425..1156611 - 1187 Protein_1134 serine/threonine protein kinase -
G6N07_RS05750 1156677..1157087 - 411 WP_085189703.1 VapC toxin family PIN domain ribonuclease Toxin
G6N07_RS05755 1157078..1157296 - 219 WP_179959952.1 hypothetical protein Antitoxin
G6N07_RS05760 1157344..1157655 + 312 WP_085189714.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
G6N07_RS05765 1157652..1157963 + 312 WP_085189705.1 hypothetical protein -
G6N07_RS05770 1159161..1159718 - 558 WP_085189707.1 HPP family protein -
G6N07_RS19875 1159852..1160427 + 576 WP_085189708.1 CGNR zinc finger domain-containing protein -
G6N07_RS05780 1160654..1160803 - 150 Protein_1141 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14820.03 Da        Isoelectric Point: 5.1634

>T36322 WP_085189703.1 NZ_AP022605:c1157087-1156677 [Mycolicibacterium doricum]
VAVTNWLIDKSAYTRLVASPDAQAWVERIERGLVRMSTVTRLQIGYSFRNGPQARSESGAPPLALMPLEYLTPAAEDRAV
DVQLQLADRGLHRAPAIPDLLVAAVAEMAGLTVLALDTDFDLIAQVTGQAVERLRR

Download         Length: 411 bp

>T36322 NZ_AP022605:c1157087-1156677 [Mycolicibacterium doricum]
GTGGCGGTGACCAACTGGCTCATCGACAAATCGGCCTACACGCGACTGGTCGCATCCCCAGATGCTCAGGCCTGGGTTGA
GCGCATCGAACGTGGCCTCGTGCGCATGAGCACTGTCACCCGCCTGCAAATTGGCTACTCGTTCCGGAACGGACCGCAGG
CCCGCAGCGAATCAGGCGCACCGCCGCTGGCATTGATGCCGCTCGAGTACCTGACCCCGGCCGCCGAGGACCGTGCCGTG
GACGTGCAGCTCCAGCTGGCCGACCGTGGGCTGCACCGCGCCCCCGCGATCCCGGATCTGCTCGTGGCTGCTGTCGCTGA
GATGGCCGGCCTGACCGTGCTCGCCCTCGACACGGACTTCGACCTGATCGCGCAAGTCACTGGGCAAGCAGTCGAACGGC
TGCGCCGGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7796.65 Da        Isoelectric Point: 4.4949

>AT36322 WP_179959952.1 NZ_AP022605:c1157296-1157078 [Mycolicibacterium doricum]
VLIRGLSDAAIARIDADAAARGLSRQEYLRTRFETEGSVSASTRTMTVDDLRRAAAAATDLDDPDVMDAAWR

Download         Length: 219 bp

>AT36322 NZ_AP022605:c1157296-1157078 [Mycolicibacterium doricum]
GTGCTGATCCGCGGGCTGTCCGACGCGGCGATCGCGCGTATCGACGCCGACGCCGCCGCACGCGGTCTCTCGCGCCAAGA
GTATCTGCGAACCAGATTCGAGACCGAAGGTTCAGTGAGCGCCTCCACGCGGACCATGACCGTCGACGATCTACGACGCG
CCGCCGCCGCGGCGACCGACCTCGACGATCCCGACGTTATGGACGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References