36320

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 527631..528283 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N07_RS02640 Protein ID WP_085190356.1
Coordinates 527631..528062 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N07_RS02645 Protein ID WP_085190354.1
Coordinates 528059..528283 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS02620 523513..523941 - 429 WP_085190363.1 hypothetical protein -
G6N07_RS02625 524023..525384 - 1362 WP_085190361.1 hypothetical protein -
G6N07_RS02630 525980..526513 - 534 WP_085190359.1 hypothetical protein -
G6N07_RS02635 526791..527363 - 573 WP_085190358.1 Uma2 family endonuclease -
G6N07_RS02640 527631..528062 - 432 WP_085190356.1 PIN domain nuclease Toxin
G6N07_RS02645 528059..528283 - 225 WP_085190354.1 antitoxin Antitoxin
G6N07_RS02650 528549..529469 + 921 WP_085190461.1 endonuclease/exonuclease/phosphatase family protein -
G6N07_RS02655 529555..531525 - 1971 WP_085190352.1 ATP-dependent zinc metalloprotease FtsH -
G6N07_RS02660 531965..532228 + 264 WP_085190350.1 hypothetical protein -
G6N07_RS02665 532301..532600 + 300 WP_085190347.1 DUF4193 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15782.04 Da        Isoelectric Point: 4.9796

>T36320 WP_085190356.1 NZ_AP022605:c528062-527631 [Mycolicibacterium doricum]
VTEQEWLIDKSALVRLAQSPDRDLWANRIERGMIHISTLTRLEIGYSAQSGDVARREFREPPLAAMPVEYLTPKIEDRAL
EVLILLADRGQHRGPSIPDLVIAATAELAGLTVLHVDKDFDIITALTGQPANRLAYSGTAKAE

Download         Length: 432 bp

>T36320 NZ_AP022605:c528062-527631 [Mycolicibacterium doricum]
GTGACCGAACAGGAGTGGCTGATCGACAAGTCCGCCCTCGTCCGGCTTGCACAGAGTCCGGATCGGGACCTCTGGGCGAA
CCGCATTGAGCGGGGAATGATCCACATCAGCACTTTGACTCGCCTGGAAATTGGCTATTCGGCGCAATCCGGTGATGTCG
CCCGCCGTGAGTTCCGCGAGCCGCCCTTGGCGGCAATGCCAGTCGAGTATTTGACGCCGAAGATAGAGGACCGCGCGTTG
GAAGTGCTGATTCTGCTGGCCGATCGGGGTCAGCACCGCGGTCCATCAATTCCCGACCTCGTCATCGCGGCCACCGCCGA
GCTTGCCGGGTTGACAGTCCTGCACGTCGACAAAGACTTCGACATCATCACCGCGCTGACCGGACAGCCGGCAAATCGCC
TGGCCTACAGCGGCACCGCCAAGGCGGAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8350.55 Da        Isoelectric Point: 6.3199

>AT36320 WP_085190354.1 NZ_AP022605:c528283-528059 [Mycolicibacterium doricum]
MSDVLIRNIPDDVLAGLDARAAELGLSRVEYIRRRLAQDARTMRVRVTSDDLRRLGQVAAGLADEELMREAWGR

Download         Length: 225 bp

>AT36320 NZ_AP022605:c528283-528059 [Mycolicibacterium doricum]
ATGAGTGACGTCTTGATCCGGAACATTCCAGACGACGTGCTGGCCGGCCTGGATGCGCGAGCGGCTGAGTTGGGCTTGTC
GCGCGTCGAGTACATCCGCCGCCGCCTTGCTCAGGATGCCCGGACGATGCGCGTTCGGGTCACCAGTGATGACCTTCGCC
GGCTCGGACAGGTTGCGGCTGGCCTCGCTGATGAGGAGCTCATGCGCGAGGCTTGGGGTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References