Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 471784..472502 Replicon chromosome
Accession NZ_AP022605
Organism Mycolicibacterium doricum strain JCM 12405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N07_RS02395 Protein ID WP_085190431.1
Coordinates 472092..472502 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N07_RS02390 Protein ID WP_099050205.1
Coordinates 471784..472095 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N07_RS02350 467133..467486 - 354 Protein_468 hypothetical protein -
G6N07_RS02355 467595..468617 + 1023 Protein_469 IS3 family transposase -
G6N07_RS02360 468640..468807 - 168 WP_163784056.1 hypothetical protein -
G6N07_RS02365 468804..469247 - 444 WP_133055535.1 hypothetical protein -
G6N07_RS02370 469383..469676 - 294 WP_085190434.1 hypothetical protein -
G6N07_RS02375 469690..471093 - 1404 WP_133055534.1 endonuclease -
G6N07_RS02380 471086..471301 + 216 WP_133055533.1 hypothetical protein -
G6N07_RS02385 471425..471682 - 258 WP_099050206.1 ESX-1 secretion-associated protein -
G6N07_RS02390 471784..472095 + 312 WP_099050205.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G6N07_RS02395 472092..472502 + 411 WP_085190431.1 PIN domain-containing protein Toxin
G6N07_RS02400 472611..473039 + 429 WP_085190429.1 nitroreductase family deazaflavin-dependent oxidoreductase -
G6N07_RS02405 473096..473536 + 441 Protein_479 NERD domain-containing protein -
G6N07_RS02410 473711..474052 + 342 WP_163784058.1 TNT domain-containing protein -
G6N07_RS02415 474049..474576 + 528 WP_085190425.1 hypothetical protein -
G6N07_RS02420 474714..475268 + 555 WP_099050209.1 NUDIX hydrolase -
G6N07_RS02425 475331..476761 + 1431 WP_085190423.1 DUF3375 domain-containing protein -
G6N07_RS02430 476758..477336 + 579 WP_085190421.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 449780..474576 24796
- flank IS/Tn - - 467595..468617 1022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(12-128)

Antitoxin

Post-segregation antitoxin CcdA

(34-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14640.90 Da        Isoelectric Point: 8.0718

>T36319 WP_085190431.1 NZ_AP022605:472092-472502 [Mycolicibacterium doricum]
MSASSAPREQVVIDASAMVDLLARAGDRYSAVRARLARTVMHAPAHFDAEVLSALGRLQRGGALTVVQVDAALDELRRAP
VTRHCLTPLVVGAWARRDTLRLADALYVELADTAGLMLLTTDQRLARAWPSADAII

Download         Length: 411 bp

>T36319 NZ_AP022605:472092-472502 [Mycolicibacterium doricum]
ATGAGCGCGTCATCCGCGCCGCGGGAGCAGGTGGTCATCGACGCGAGTGCCATGGTGGATCTCCTCGCTCGCGCAGGTGA
TCGGTACTCGGCGGTGCGAGCGCGACTGGCGCGGACGGTGATGCATGCACCGGCGCACTTCGATGCCGAGGTGCTGTCGG
CACTTGGGCGACTGCAGCGCGGCGGTGCGCTCACCGTCGTGCAGGTGGACGCAGCACTGGACGAACTCCGGCGGGCACCG
GTGACTCGGCACTGTCTCACGCCCCTGGTCGTCGGAGCGTGGGCGCGCCGCGACACGCTCCGACTGGCCGATGCGCTCTA
CGTCGAGCTGGCAGATACCGCCGGTCTGATGTTGCTGACCACGGACCAAAGGCTGGCACGTGCTTGGCCTTCGGCTGACG
CAATCATCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11372.76 Da        Isoelectric Point: 5.1953

>AT36319 WP_099050205.1 NZ_AP022605:471784-472095 [Mycolicibacterium doricum]
MRQIRAGDSVGLRQGARRSERPLTYVCRFVCMARLNVYVPDELAERARERGLNVSALTQAAIRAELEDAATDAWLESLDA
RSTSARHDDVLAAIDAARDELGT

Download         Length: 312 bp

>AT36319 NZ_AP022605:471784-472095 [Mycolicibacterium doricum]
ATGCGGCAAATTCGGGCAGGGGATTCCGTAGGGTTAAGGCAAGGCGCGCGGAGGAGCGAGCGGCCGCTGACATATGTGTG
TAGATTTGTGTGTATGGCCCGGCTCAACGTGTACGTCCCCGATGAATTGGCGGAGCGGGCCAGAGAGCGCGGATTGAATG
TTTCGGCGCTGACTCAAGCCGCGATTCGCGCAGAACTAGAAGATGCTGCGACGGACGCGTGGCTTGAGAGCTTGGATGCC
AGGAGCACCAGTGCGCGGCATGACGACGTGTTGGCTGCCATCGACGCCGCCCGCGACGAACTTGGAACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References