Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4127123..4127811 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N52_RS19470 Protein ID WP_126333967.1
Coordinates 4127123..4127536 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N52_RS19475 Protein ID WP_126333968.1
Coordinates 4127533..4127811 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS19450 4123034..4123309 - 276 WP_126333963.1 hypothetical protein -
G6N52_RS19455 4123586..4124125 - 540 WP_126333964.1 hypothetical protein -
G6N52_RS19460 4124432..4125628 + 1197 WP_126333965.1 hypothetical protein -
G6N52_RS19465 4125647..4127113 + 1467 WP_126333966.1 wax ester/triacylglycerol synthase family O-acyltransferase -
G6N52_RS19470 4127123..4127536 - 414 WP_126333967.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N52_RS19475 4127533..4127811 - 279 WP_126333968.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N52_RS19480 4127942..4128760 + 819 WP_126333969.1 TIGR03560 family F420-dependent LLM class oxidoreductase -
G6N52_RS19485 4129196..4130896 + 1701 WP_126333970.1 class I poly(R)-hydroxyalkanoic acid synthase -
G6N52_RS19490 4131007..4132227 - 1221 WP_126333971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4121413..4122663 1250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14857.94 Da        Isoelectric Point: 4.7569

>T36318 WP_126333967.1 NZ_AP022604:c4127536-4127123 [Mycolicibacterium chitae]
MIYLDTSALTKLLVAEAETPDLQSWLLEQRDHGEDHAVTSALGRVELMRAVARLGEPGLHERALYLLDGLDILPLTDAVI
TLAETIGPARLRSLDAIHLASAAQIRRELTTFVTYDHRLLEGCRAVGFDTASPGGSA

Download         Length: 414 bp

>T36318 NZ_AP022604:c4127536-4127123 [Mycolicibacterium chitae]
TTGATCTACCTGGACACGTCTGCCCTGACCAAGCTGCTCGTCGCCGAAGCCGAGACACCAGACCTGCAGTCGTGGCTCCT
CGAACAGCGCGACCACGGCGAAGACCACGCGGTGACGAGCGCCCTCGGCCGTGTCGAATTGATGAGAGCTGTTGCGCGGC
TGGGGGAGCCGGGACTTCACGAGCGTGCACTCTATCTGCTCGACGGCCTGGACATTCTGCCGTTGACCGACGCCGTGATC
ACCTTGGCCGAAACGATCGGCCCCGCCCGCCTGCGCTCACTGGACGCGATTCACCTTGCCTCGGCCGCCCAGATCAGGCG
TGAGCTCACGACGTTCGTCACCTACGACCACCGGCTGTTGGAGGGCTGTCGCGCAGTCGGTTTCGACACCGCGTCGCCGG
GCGGCTCGGCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10349.70 Da        Isoelectric Point: 5.2187

>AT36318 WP_126333968.1 NZ_AP022604:c4127811-4127533 [Mycolicibacterium chitae]
MEAIGVRELRQHASRYLARVEAGEELGVTNNGRLVARLVPVQDVERSRESLIEAGVLTPANRPRNLFDIIATPDPGRERT
LSEVLSEMRDER

Download         Length: 279 bp

>AT36318 NZ_AP022604:c4127811-4127533 [Mycolicibacterium chitae]
ATGGAGGCTATCGGAGTCCGCGAACTGCGGCAACACGCATCGCGATACCTCGCGCGGGTTGAAGCCGGTGAGGAACTCGG
CGTCACCAACAACGGCCGACTCGTCGCCAGACTGGTCCCGGTGCAGGACGTCGAACGGTCCCGCGAATCCCTGATCGAGG
CCGGCGTTCTGACCCCGGCCAATCGGCCGCGGAACCTCTTCGACATCATTGCCACGCCAGATCCTGGCCGTGAGCGCACC
CTGTCGGAAGTTCTCAGCGAGATGCGCGACGAACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References