Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4119814..4120349 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N52_RS19435 Protein ID WP_126333961.1
Coordinates 4120017..4120349 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N52_RS19430 Protein ID WP_126333960.1
Coordinates 4119814..4120020 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS19400 4115943..4116557 + 615 WP_126336824.1 hypothetical protein -
G6N52_RS19405 4116672..4116917 + 246 WP_126333955.1 plasmid stabilization protein -
G6N52_RS19410 4116914..4117342 + 429 WP_126333956.1 type II toxin-antitoxin system VapC family toxin -
G6N52_RS19415 4117471..4117680 - 210 WP_126333957.1 hypothetical protein -
G6N52_RS19420 4117878..4118885 - 1008 WP_126333958.1 zinc-dependent alcohol dehydrogenase family protein -
G6N52_RS19425 4119143..4119694 - 552 WP_126333959.1 YaeQ family protein -
G6N52_RS19430 4119814..4120020 + 207 WP_126333960.1 DUF3018 family protein Antitoxin
G6N52_RS19435 4120017..4120349 + 333 WP_126333961.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N52_RS19440 4120901..4121326 - 426 WP_126333962.1 hypothetical protein -
G6N52_RS19445 4121413..4122663 - 1251 WP_126333404.1 IS256 family transposase -
G6N52_RS19450 4123034..4123309 - 276 WP_126333963.1 hypothetical protein -
G6N52_RS19455 4123586..4124125 - 540 WP_126333964.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4114541..4115791 1250
- flank IS/Tn - - 4121413..4122663 1250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11876.67 Da        Isoelectric Point: 7.2039

>T36317 WP_126333961.1 NZ_AP022604:4120017-4120349 [Mycolicibacterium chitae]
VNRGEIWTVAGGIYAGKSRPAVIVQDDLFDATGSVTVAPMTSTLLDAPLMRIRITGGQGRLSGLDHDSDVMIDQLTTVRR
SNVHVRVGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

>T36317 NZ_AP022604:4120017-4120349 [Mycolicibacterium chitae]
GTGAACCGAGGGGAGATCTGGACGGTAGCGGGGGGCATCTACGCGGGGAAGTCACGTCCGGCGGTGATCGTTCAGGATGA
CCTCTTTGACGCCACGGGTTCAGTGACGGTTGCGCCCATGACCAGCACGTTGTTGGATGCGCCGTTGATGCGCATTCGGA
TAACCGGCGGACAAGGTCGGCTATCGGGACTGGACCACGACAGCGACGTGATGATCGATCAGCTCACCACCGTCAGAAGG
TCGAACGTTCACGTCCGAGTCGGCCGGCTCACTGCGGAACAAGTCGTCGAGGTGGAGCGGGCGATGATGGCATTCCTTGG
ACTGGCCCGGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7973.77 Da        Isoelectric Point: 4.6286

>AT36317 WP_126333960.1 NZ_AP022604:4119814-4120020 [Mycolicibacterium chitae]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADESNDDQDFIEAVSTPWDEE

Download         Length: 207 bp

>AT36317 NZ_AP022604:4119814-4120020 [Mycolicibacterium chitae]
ATGGCGGTGAGGGACAGGGTAGGCGAGTACAGGCGGCGGATGCGCGAGCGCGGCCTGCGGCCGCTGCAAGTCTGGGTGCC
GGACGTGCGCACTGAGAGTTTCGCCGCCGAGGCGCATCGCCAGGCTTCGTTGGTCGCAAGAGCGGACGAGAGCAACGACG
ACCAGGACTTTATCGAGGCTGTCTCGACGCCCTGGGATGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References