Detailed information of TA system TA036316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 4079236..4080232
• Replicon: chromosome
• Accession: NZ_AP022604
• Organism: Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N52_RS19195
• Protein ID: WP_126333916.1
• Coordinates: 4079236..4079814 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G6N52_RS19200
• Protein ID: WP_126333917.1
• Coordinates: 4079843..4080232 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N52_RS19175	4074860..4075363	-	504	WP_126333912.1	pyridoxamine 5'-phosphate oxidase family protein	-
G6N52_RS19180	4075360..4075959	-	600	WP_126333913.1	TetR/AcrR family transcriptional regulator	-
G6N52_RS19185	4075986..4077419	-	1434	WP_126333914.1	rifampin monooxygenase	-
G6N52_RS19190	4077577..4079157	-	1581	WP_126333915.1	serine hydrolase	-
G6N52_RS19195	4079236..4079814	-	579	WP_126333916.1	zeta toxin family protein	Toxin
G6N52_RS19200	4079843..4080232	-	390	WP_126333917.1	hypothetical protein	Antitoxin
G6N52_RS19205	4080305..4080901	-	597	WP_126336822.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
G6N52_RS26215	4081017..4081175	-	159	WP_170217437.1	hypothetical protein	-
G6N52_RS19210	4081337..4081813	+	477	WP_126333918.1	transcriptional repressor	-
G6N52_RS19215	4081803..4084052	+	2250	WP_126333919.1	catalase/peroxidase HPI	-
G6N52_RS19220	4084129..4084668	+	540	WP_126333920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-145)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21002.99 Da
• Isoelectric Point: 8.9334

>T36316 WP_126333916.1 NZ_AP022604:c4079814-4079236 [Mycolicibacterium chitae]
MKRLDLVIGCNGAGKSTFVELTLAPLLPGSAFVNADEIAKRRWPADAAEHAYEAARTAAATRARLIELGESFIAETVFSH
PSKLELVDTALAAGYVVALHVVLIPEELAVLRVAHRVTAGGHAVPENKIRERYGRVWELAARAAQRVDSATFYDNSTRRG
PRIVAQLHGGFIVGQPRWPDWTPTAFTDRWPA

Nucleotide

• Length: 579 bp

>T36316 NZ_AP022604:c4079814-4079236 [Mycolicibacterium chitae]
ATGAAGCGGCTGGACCTCGTCATCGGCTGCAACGGCGCCGGAAAATCTACCTTCGTGGAGCTGACCCTGGCGCCCCTGCT
GCCGGGTAGCGCGTTCGTCAATGCCGACGAGATCGCCAAGCGGCGTTGGCCCGCTGATGCCGCCGAACACGCCTACGAGG
CCGCGCGTACCGCGGCCGCCACCCGCGCCCGGCTCATCGAACTCGGTGAATCGTTCATCGCCGAGACCGTGTTCTCACAC
CCATCGAAGCTCGAACTCGTCGACACGGCCCTCGCAGCCGGCTACGTCGTGGCCCTGCACGTCGTGCTGATCCCCGAAGA
GCTCGCGGTGCTGCGCGTGGCCCACCGCGTCACCGCCGGCGGACACGCGGTGCCCGAGAACAAGATCCGGGAACGCTACG
GGCGGGTATGGGAGCTGGCCGCCCGCGCCGCGCAGCGGGTCGATTCAGCCACGTTCTACGACAACAGCACCCGACGAGGA
CCTCGTATCGTCGCCCAACTACACGGCGGTTTCATCGTCGGTCAGCCCCGCTGGCCGGACTGGACGCCAACGGCGTTCAC
CGACCGCTGGCCCGCCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13886.32 Da
• Isoelectric Point: 4.7561

>AT36316 WP_126333917.1 NZ_AP022604:c4080232-4079843 [Mycolicibacterium chitae]
MTDTTDRVTRFAADLVDAAAVEGARQSRSAKQQLDHWARVGRAVSSQHSAARRKVEAALAGETPLRNLSPEEGVAFNAEI
TAALEENLARTDYGQILADRGVTTVALDDDGQIVQYRPDGTTAVLEPRP

Nucleotide

• Length: 390 bp

>AT36316 NZ_AP022604:c4080232-4079843 [Mycolicibacterium chitae]
ATGACGGATACCACCGACCGGGTGACCCGGTTCGCCGCGGACCTCGTCGATGCCGCGGCGGTCGAAGGTGCCCGCCAGAG
CCGCTCGGCCAAACAACAACTCGACCACTGGGCGCGGGTCGGCCGCGCGGTCTCCAGCCAGCACAGCGCCGCACGCCGCA
AGGTCGAAGCCGCGTTGGCCGGCGAAACCCCCCTGCGCAACCTCAGCCCCGAGGAGGGCGTGGCGTTCAACGCAGAGATC
ACCGCCGCCCTCGAGGAAAACTTGGCGCGCACCGACTACGGGCAGATTCTTGCCGACCGCGGCGTGACCACCGTCGCCCT
CGATGACGATGGACAGATCGTGCAGTACCGGCCCGATGGAACGACGGCGGTGCTGGAACCTCGTCCGTGA