Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 3465104..3465723 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N52_RS16385 Protein ID WP_126336755.1
Coordinates 3465346..3465723 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N52_RS16380 Protein ID WP_126333443.1
Coordinates 3465104..3465322 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS16355 3460910..3461860 + 951 WP_126333438.1 alpha/beta fold hydrolase -
G6N52_RS16360 3461857..3462483 + 627 WP_126333439.1 TetR/AcrR family transcriptional regulator -
G6N52_RS16365 3462485..3463030 - 546 WP_163792083.1 DUF4333 domain-containing protein -
G6N52_RS16370 3463030..3464469 - 1440 WP_126333441.1 peptidase -
G6N52_RS16375 3464571..3465077 + 507 WP_126333442.1 O-acetyl-ADP-ribose deacetylase -
G6N52_RS16380 3465104..3465322 + 219 WP_126333443.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
G6N52_RS16385 3465346..3465723 + 378 WP_126336755.1 PIN domain-containing protein Toxin
G6N52_RS16390 3465764..3466711 + 948 WP_126333444.1 mechanosensitive ion channel family protein -
G6N52_RS16395 3466715..3468334 - 1620 WP_126333445.1 peptide chain release factor 3 -
G6N52_RS16400 3468463..3468816 + 354 WP_163792086.1 hypothetical protein -
G6N52_RS16405 3468842..3469678 + 837 WP_126333447.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(2-123)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13377.43 Da        Isoelectric Point: 6.7266

>T36315 WP_126336755.1 NZ_AP022604:3465346-3465723 [Mycolicibacterium chitae]
VVIDASAMVDLVARTDRFAAVRARLARTVMHAPAHFDAEVLSALGRLQRAAVLTVAEVDAALDELRQAPVTRHALPSLLS
GAWARRDTLRLADALYVELAETAGLTLLTTDQRLARAAQVADVIA

Download         Length: 378 bp

>T36315 NZ_AP022604:3465346-3465723 [Mycolicibacterium chitae]
GTGGTCATCGACGCAAGTGCCATGGTGGACCTCGTCGCCCGCACGGATCGCTTCGCCGCAGTCCGGGCAAGGCTGGCGCG
GACGGTGATGCATGCACCGGCCCACTTCGACGCCGAAGTGCTCTCGGCGCTGGGACGCCTGCAACGTGCGGCTGTACTGA
CCGTGGCGGAAGTCGATGCAGCCCTTGATGAACTCCGGCAGGCGCCGGTGACACGGCACGCTCTCCCGTCGCTGCTTTCC
GGCGCGTGGGCGCGTCGCGACACGTTGCGCCTGGCTGATGCGCTCTACGTCGAATTGGCCGAGACGGCCGGTTTGACCTT
GCTGACGACGGACCAAAGGTTGGCGCGCGCGGCGCAAGTGGCCGACGTCATCGCCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7801.65 Da        Isoelectric Point: 4.3939

>AT36315 WP_126333443.1 NZ_AP022604:3465104-3465322 [Mycolicibacterium chitae]
MARLNVYVPDELAERARARGLNVSALTQAAIRAELDDSATDAWLEALAPRSTRARHDDVLDAIDAARDELGA

Download         Length: 219 bp

>AT36315 NZ_AP022604:3465104-3465322 [Mycolicibacterium chitae]
ATGGCTCGCTTGAACGTGTACGTGCCCGACGAACTGGCTGAACGCGCCCGGGCGCGGGGCCTGAACGTCTCGGCGCTGAC
GCAGGCCGCGATCCGCGCGGAGTTGGACGACTCCGCCACCGACGCGTGGCTCGAGGCCTTGGCGCCGAGAAGCACCCGGG
CGCGGCATGACGATGTGCTGGATGCCATCGACGCCGCCCGCGACGAACTCGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References