Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3458314..3458957 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N52_RS16345 Protein ID WP_126333436.1
Coordinates 3458568..3458957 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N52_RS16340 Protein ID WP_126333435.1
Coordinates 3458314..3458568 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS16310 3454062..3454433 - 372 WP_126333430.1 STAS/SEC14 domain-containing protein -
G6N52_RS16315 3454523..3455191 + 669 WP_126333431.1 thioredoxin domain-containing protein -
G6N52_RS16320 3455202..3455513 - 312 WP_126336754.1 hypothetical protein -
G6N52_RS16325 3455628..3457073 - 1446 WP_126333432.1 ADP-ribosylglycohydrolase family protein -
G6N52_RS16330 3457092..3457427 - 336 WP_126333433.1 DUF732 domain-containing protein -
G6N52_RS16335 3457664..3458266 + 603 WP_126333434.1 DUF2510 domain-containing protein -
G6N52_RS16340 3458314..3458568 + 255 WP_126333435.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N52_RS16345 3458568..3458957 + 390 WP_126333436.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N52_RS16350 3459549..3460913 + 1365 WP_126333437.1 NAD(P)-binding domain-containing protein -
G6N52_RS16355 3460910..3461860 + 951 WP_126333438.1 alpha/beta fold hydrolase -
G6N52_RS16360 3461857..3462483 + 627 WP_126333439.1 TetR/AcrR family transcriptional regulator -
G6N52_RS16365 3462485..3463030 - 546 WP_163792083.1 DUF4333 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13945.75 Da        Isoelectric Point: 4.5486

>T36314 WP_126333436.1 NZ_AP022604:3458568-3458957 [Mycolicibacterium chitae]
MVIDTSALVAMLTDEADAVLLEARVAEDPVRTMSTASYLETAIVIEARYGEAGGRELDLWLHRASVDLVPVTADQAEVAR
RAYRQYGKGCHPAGLNYGDCFSYALAKVNGQPLLFKGDGFQHTDVVAAQ

Download         Length: 390 bp

>T36314 NZ_AP022604:3458568-3458957 [Mycolicibacterium chitae]
ATGGTCATCGACACCTCTGCGCTGGTCGCAATGTTGACCGACGAAGCCGACGCAGTACTTCTCGAAGCCCGCGTGGCAGA
GGATCCGGTGCGGACGATGTCCACCGCGTCGTATTTGGAGACGGCGATTGTGATCGAAGCTCGATACGGTGAAGCCGGCG
GTCGCGAATTGGACCTATGGCTCCATCGGGCATCGGTGGACCTCGTCCCTGTCACCGCTGACCAAGCTGAGGTTGCGCGG
CGCGCCTACCGGCAGTACGGCAAGGGGTGCCACCCTGCCGGCCTGAACTACGGCGATTGCTTCTCCTACGCTTTGGCCAA
GGTGAACGGTCAGCCGTTGCTGTTCAAGGGCGATGGCTTTCAGCACACGGATGTCGTTGCAGCCCAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9295.66 Da        Isoelectric Point: 7.9886

>AT36314 WP_126333435.1 NZ_AP022604:3458314-3458568 [Mycolicibacterium chitae]
MALSIKDPEADRLARQLAAQTGETLTEVVVVALRERLARQSNRVRVAPLREELAAIRRRCAALEVKDDRAAEAILGYDDR
GLPS

Download         Length: 255 bp

>AT36314 NZ_AP022604:3458314-3458568 [Mycolicibacterium chitae]
ATGGCACTAAGTATCAAAGATCCCGAGGCCGACCGACTGGCCCGGCAACTCGCTGCGCAGACCGGAGAGACTTTGACGGA
AGTGGTGGTGGTGGCGTTGCGTGAGCGCCTGGCGCGCCAATCCAATCGGGTACGCGTCGCTCCACTACGCGAGGAACTCG
CGGCGATCCGACGGCGCTGCGCGGCACTCGAGGTCAAGGATGACCGCGCCGCCGAGGCGATCTTGGGCTACGACGACCGC
GGTCTACCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References