Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 2382489..2383149 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N52_RS11295 Protein ID WP_126332524.1
Coordinates 2382715..2383149 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N52_RS11290 Protein ID WP_126332523.1
Coordinates 2382489..2382701 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS11280 2378563..2380041 + 1479 WP_126336664.1 serine hydrolase -
G6N52_RS11285 2380038..2382443 + 2406 WP_126332522.1 cation-translocating P-type ATPase -
G6N52_RS11290 2382489..2382701 + 213 WP_126332523.1 antitoxin Antitoxin
G6N52_RS11295 2382715..2383149 + 435 WP_126332524.1 SRPBCC family protein Toxin
G6N52_RS11300 2383159..2384733 - 1575 WP_179967159.1 GAF domain-containing sensor histidine kinase -
G6N52_RS11305 2384726..2385376 - 651 WP_126332525.1 response regulator transcription factor -
G6N52_RS11310 2385386..2385736 - 351 WP_126332526.1 hypothetical protein -
G6N52_RS11315 2385771..2386208 - 438 WP_126332527.1 cupin domain-containing protein -
G6N52_RS11320 2386332..2387882 + 1551 WP_126332528.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15596.18 Da        Isoelectric Point: 9.8777

>T36313 WP_126332524.1 NZ_AP022604:2382715-2383149 [Mycolicibacterium chitae]
VAKLSVSVDVPLPPEQAWECAADLSRYKEWLTIHRVWRSALPETLEKGTTLDSIVEVKGMANRVKWTIVHYKPPQAMTLN
GDGRGGVKIKLMAKITPKGDGSVVTFDTHLGGPALFGPIGMVVAGALKGDIRESLNNFVKVFTG

Download         Length: 435 bp

>T36313 NZ_AP022604:2382715-2383149 [Mycolicibacterium chitae]
GTGGCGAAGCTATCTGTCTCTGTGGACGTGCCGCTCCCACCCGAGCAGGCCTGGGAGTGCGCGGCTGATCTGTCCCGTTA
CAAGGAGTGGCTGACCATCCATCGGGTGTGGCGCAGCGCGCTGCCGGAAACGCTGGAAAAGGGCACCACCCTGGACTCGA
TCGTCGAGGTCAAGGGGATGGCCAACCGGGTCAAGTGGACGATCGTGCATTACAAGCCCCCGCAGGCGATGACGCTCAAC
GGCGACGGCCGCGGCGGCGTCAAGATCAAGCTGATGGCCAAGATCACGCCCAAGGGCGACGGGTCGGTGGTCACCTTCGA
CACCCACCTCGGCGGGCCGGCGCTGTTCGGGCCCATCGGGATGGTGGTCGCGGGCGCGCTCAAGGGCGACATCCGCGAGT
CGCTGAACAACTTTGTGAAGGTCTTCACGGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7410.23 Da        Isoelectric Point: 6.4571

>AT36313 WP_126332523.1 NZ_AP022604:2382489-2382701 [Mycolicibacterium chitae]
MSFLDKAKNLLGKNADKVGGAIDKAGDFVDQKTDGKYAGHVDKAQDAAKDAVQKMDPTQADPNHKDTPPA

Download         Length: 213 bp

>AT36313 NZ_AP022604:2382489-2382701 [Mycolicibacterium chitae]
ATGTCGTTCCTCGACAAGGCCAAGAACCTGCTCGGAAAGAACGCCGACAAGGTCGGCGGCGCGATCGACAAGGCCGGCGA
TTTCGTCGACCAGAAGACGGACGGCAAATACGCCGGGCACGTCGACAAGGCCCAGGACGCCGCCAAGGACGCGGTCCAGA
AGATGGATCCCACCCAGGCGGATCCCAACCATAAGGACACTCCGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References