Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 1626738..1627261 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag G6N52_RS07735 Protein ID WP_126331927.1
Coordinates 1626962..1627261 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag G6N52_RS07730 Protein ID WP_126331926.1
Coordinates 1626738..1626965 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS07700 1621769..1622095 + 327 WP_126331921.1 metalloregulator ArsR/SmtB family transcription factor -
G6N52_RS07705 1622105..1622602 + 498 WP_126331922.1 SRPBCC domain-containing protein -
G6N52_RS07710 1622626..1623978 - 1353 WP_126331923.1 TIGR01777 family oxidoreductase -
G6N52_RS07715 1624181..1624669 - 489 WP_126331924.1 hypothetical protein -
G6N52_RS07720 1624846..1625499 + 654 WP_126331925.1 response regulator transcription factor -
G6N52_RS07725 1625522..1626727 + 1206 WP_126336582.1 sensor histidine kinase -
G6N52_RS07730 1626738..1626965 + 228 WP_126331926.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N52_RS07735 1626962..1627261 + 300 WP_126331927.1 toxin Toxin
G6N52_RS07740 1627338..1628093 - 756 WP_126331928.1 helix-turn-helix transcriptional regulator -
G6N52_RS07745 1628236..1628652 + 417 WP_126331929.1 WhiB family transcriptional regulator -
G6N52_RS07750 1628662..1629480 + 819 WP_126331930.1 C40 family peptidase -
G6N52_RS07755 1629531..1629896 + 366 WP_126331931.1 DUF4226 domain-containing protein -
G6N52_RS07760 1630042..1631466 + 1425 WP_126336583.1 DUF4226 domain-containing protein -
G6N52_RS07765 1631477..1631785 + 309 WP_126331932.1 ESX-1 secretion-associated protein -
G6N52_RS07770 1631782..1632087 + 306 WP_126331933.1 DUF2694 family protein -
G6N52_RS26140 1632106..1632249 - 144 WP_170217407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-39)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10550.31 Da        Isoelectric Point: 4.6779

>T36312 WP_126331927.1 NZ_AP022604:1626962-1627261 [Mycolicibacterium chitae]
VMRPGDVAPRLDTEHELYVAVLSNSMHLTANTGRVITCPFIPGEIPADTMAMVVATERPRGVVVPELVQWLPVVALDAPI
GNIGADAVHETKTVLTALL

Download         Length: 300 bp

>T36312 NZ_AP022604:1626962-1627261 [Mycolicibacterium chitae]
GTGATGAGGCCAGGCGACGTCGCGCCGCGTCTCGACACCGAGCACGAGCTGTACGTCGCGGTGCTATCGAACTCAATGCA
TCTGACGGCCAACACCGGCCGTGTGATCACGTGCCCGTTCATCCCCGGCGAGATTCCCGCCGACACGATGGCGATGGTCG
TGGCGACGGAGCGGCCGCGCGGTGTCGTAGTACCCGAACTGGTCCAATGGCTTCCCGTGGTGGCGCTCGACGCGCCGATC
GGCAACATCGGTGCCGACGCGGTGCATGAAACGAAGACCGTCCTGACGGCTCTGTTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 7942.00 Da        Isoelectric Point: 4.5637

>AT36312 WP_126331926.1 NZ_AP022604:1626738-1626965 [Mycolicibacterium chitae]
MAKDKISVTVDAAVLAAADAHAAAAGLNRSEMIEQALRNESVRLALESYTTQTVPMLDIDSYAGMIYQANRSAGL

Download         Length: 228 bp

>AT36312 NZ_AP022604:1626738-1626965 [Mycolicibacterium chitae]
ATGGCCAAGGACAAGATATCGGTGACGGTGGACGCAGCCGTGCTCGCCGCGGCGGACGCTCACGCTGCCGCAGCCGGGCT
GAACCGGTCGGAAATGATCGAGCAGGCTCTGCGCAACGAGAGCGTGCGACTCGCGCTGGAGAGCTATACGACGCAAACCG
TCCCGATGCTCGACATCGACTCCTACGCGGGGATGATTTACCAAGCGAATCGGTCCGCTGGTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References