Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1424290..1424978 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N52_RS06725 Protein ID WP_126336367.1
Coordinates 1424541..1424978 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N52_RS06720 Protein ID WP_126336365.1
Coordinates 1424290..1424544 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS06695 1419510..1420616 - 1107 WP_126336357.1 NAD(P)/FAD-dependent oxidoreductase -
G6N52_RS06700 1420830..1421579 - 750 WP_126336359.1 SDR family oxidoreductase -
G6N52_RS06705 1421697..1422254 + 558 WP_126336361.1 TetR/AcrR family transcriptional regulator -
G6N52_RS06710 1422292..1423680 - 1389 WP_126336363.1 sodium:alanine symporter family protein -
G6N52_RS06715 1423822..1424166 - 345 WP_126337135.1 hypothetical protein -
G6N52_RS06720 1424290..1424544 + 255 WP_126336365.1 antitoxin Antitoxin
G6N52_RS06725 1424541..1424978 + 438 WP_126336367.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N52_RS06730 1424987..1425472 - 486 WP_126336369.1 SRPBCC domain-containing protein -
G6N52_RS06735 1425477..1425818 - 342 WP_179967135.1 metalloregulator ArsR/SmtB family transcription factor -
G6N52_RS06740 1425926..1426165 + 240 WP_126336371.1 hypothetical protein -
G6N52_RS06745 1426170..1427275 - 1106 Protein_1349 glutamate--cysteine ligase -
G6N52_RS06750 1427373..1427879 - 507 WP_126337139.1 peptidoglycan recognition protein family protein -
G6N52_RS06755 1428370..1429956 + 1587 WP_126336373.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(3-140)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15442.55 Da        Isoelectric Point: 6.7582

>T36311 WP_126336367.1 NZ_AP022604:1424541-1424978 [Mycolicibacterium chitae]
VKIVDANVLLYAVNSASPQHEASRRWLDGALSGSDTVGLAWVPLLAFVRLSTKTGLFPSPLPPADAMRQVVEWATAPGAT
TIAPTARHGDILHTLLAQLGTGGNIVSDAHLAALAIEHRASIVSYDNDFSRFDGVRWHTPDALVK

Download         Length: 438 bp

>T36311 NZ_AP022604:1424541-1424978 [Mycolicibacterium chitae]
GTGAAAATTGTCGATGCGAACGTACTTCTGTACGCGGTGAACTCCGCAAGCCCGCAGCACGAGGCGAGTCGCCGTTGGCT
AGATGGGGCCCTGTCCGGCTCGGACACCGTTGGCCTAGCGTGGGTGCCGCTGCTCGCCTTCGTTCGACTCAGCACGAAGA
CCGGCTTGTTCCCCTCCCCGCTGCCGCCGGCGGACGCGATGCGTCAGGTTGTTGAATGGGCCACCGCCCCGGGCGCGACG
ACTATCGCGCCTACCGCGCGGCATGGAGACATCCTGCACACCCTGCTCGCCCAGCTGGGGACCGGCGGAAACATCGTGAG
CGACGCGCACCTGGCTGCGCTGGCCATCGAACATCGTGCGTCGATTGTCAGCTACGACAACGACTTCAGCCGGTTCGACG
GCGTACGTTGGCACACCCCAGACGCGCTAGTCAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9398.69 Da        Isoelectric Point: 8.9931

>AT36311 WP_126336365.1 NZ_AP022604:1424290-1424544 [Mycolicibacterium chitae]
MRTTVTLDDDTLALVQRRMRERGVSFKTALNDAIRDGALGQPRPVHFATRTADLGVPTVNLDRALQLAAELEDEELLRKQ
RRGA

Download         Length: 255 bp

>AT36311 NZ_AP022604:1424290-1424544 [Mycolicibacterium chitae]
ATGCGTACGACAGTCACTCTTGACGATGACACGCTGGCGTTGGTTCAGCGGCGGATGCGCGAACGCGGCGTCTCTTTCAA
GACCGCACTCAACGACGCGATCCGCGATGGCGCCCTTGGCCAACCACGTCCCGTCCACTTCGCTACCCGGACCGCCGATC
TAGGGGTACCGACAGTGAATCTGGACCGCGCACTGCAACTCGCCGCCGAACTCGAAGACGAGGAACTACTGCGCAAGCAA
CGGCGTGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References