Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 399622..400195 Replicon chromosome
Accession NZ_AP022604
Organism Mycolicibacterium chitae strain JCM 12403

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N52_RS02055 Protein ID WP_126335451.1
Coordinates 399845..400195 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N52_RS02050 Protein ID WP_126335450.1
Coordinates 399622..399858 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N52_RS02035 396335..396652 + 318 WP_126335447.1 WhiB family transcriptional regulator -
G6N52_RS02040 396681..397187 + 507 WP_126335448.1 cupin domain-containing protein -
G6N52_RS02045 397322..399022 + 1701 WP_126335449.1 DEAD/DEAH box helicase -
G6N52_RS02050 399622..399858 + 237 WP_126335450.1 antitoxin Antitoxin
G6N52_RS02055 399845..400195 + 351 WP_126335451.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N52_RS02060 400285..401103 - 819 WP_126335452.1 adenylate/guanylate cyclase domain-containing protein -
G6N52_RS02065 401143..401640 - 498 WP_126335453.1 polyketide cyclase -
G6N52_RS02070 401693..402508 - 816 WP_126335454.1 HAD-IIA family hydrolase -
G6N52_RS02075 402541..403992 - 1452 WP_126335455.1 PH domain-containing protein -
G6N52_RS02080 403989..404465 - 477 WP_126336996.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12207.17 Da        Isoelectric Point: 10.6484

>T36310 WP_126335451.1 NZ_AP022604:399845-400195 [Mycolicibacterium chitae]
MASTEDPRRGQLWLVALGAARPGEPGKHRPAVIVSTEQLLTGEAAELVVVVPVSSSRVATPLRPTLTAADGVDADSVAVC
RAVRGVARARLVRRLGTLSESTMGQVDRALKMILDL

Download         Length: 351 bp

>T36310 NZ_AP022604:399845-400195 [Mycolicibacterium chitae]
ATGGCCTCGACTGAGGATCCCCGGCGAGGCCAGCTGTGGCTCGTTGCACTGGGCGCAGCCCGGCCGGGGGAACCGGGCAA
ACACCGCCCGGCCGTCATCGTTTCGACGGAGCAGCTGTTGACCGGTGAGGCTGCCGAACTTGTTGTGGTCGTACCGGTGT
CGAGTTCACGGGTCGCGACTCCGTTGCGGCCGACGCTGACCGCGGCGGACGGGGTGGACGCCGACAGTGTCGCGGTCTGT
CGCGCGGTCCGCGGCGTGGCCCGCGCCAGGTTGGTGCGTCGACTCGGAACGCTCTCGGAGTCAACGATGGGCCAGGTGGA
CCGCGCGTTGAAGATGATCTTGGATCTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8399.14 Da        Isoelectric Point: 4.0834

>AT36310 WP_126335450.1 NZ_AP022604:399622-399858 [Mycolicibacterium chitae]
MATATTTIRVPVTVRDRLAAQARERGVSVASLLEEWSARAEREAAFAAERAATLAEADDPNVADEERDWAQADADGLD

Download         Length: 237 bp

>AT36310 NZ_AP022604:399622-399858 [Mycolicibacterium chitae]
ATGGCTACCGCAACAACTACGATCCGGGTGCCGGTGACCGTGCGCGATCGACTCGCGGCGCAAGCGCGTGAGCGTGGCGT
GAGCGTGGCGTCACTGCTGGAGGAATGGAGCGCTCGAGCTGAGCGCGAGGCCGCGTTTGCCGCCGAACGGGCAGCGACGT
TGGCCGAGGCCGACGACCCGAACGTGGCCGACGAGGAGCGTGACTGGGCTCAGGCGGATGCCGATGGCCTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References