Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3985692..3986254 Replicon chromosome
Accession NZ_AP022603
Organism Mycolicibacterium fallax strain JCM 6405

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N10_RS19190 Protein ID WP_085092509.1
Coordinates 3985692..3986021 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N10_RS19195 Protein ID WP_085092496.1
Coordinates 3986018..3986254 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N10_RS19165 3981702..3982373 - 672 WP_085092500.1 hypothetical protein -
G6N10_RS19170 3982390..3982542 + 153 WP_163742601.1 hypothetical protein -
G6N10_RS19175 3982694..3983620 - 927 WP_085092498.1 hypothetical protein -
G6N10_RS19180 3984155..3984700 - 546 WP_179962857.1 hypothetical protein -
G6N10_RS19185 3984796..3985686 + 891 WP_085092497.1 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase -
G6N10_RS19190 3985692..3986021 - 330 WP_085092509.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N10_RS19195 3986018..3986254 - 237 WP_085092496.1 antitoxin MazE5 Antitoxin
G6N10_RS19200 3986430..3986858 + 429 WP_085092495.1 hypothetical protein -
G6N10_RS19205 3986862..3988145 - 1284 WP_085092494.1 hypothetical protein -
G6N10_RS19210 3988259..3989230 - 972 WP_085092493.1 pirin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11711.55 Da        Isoelectric Point: 8.5738

>T36309 WP_085092509.1 NZ_AP022603:c3986021-3985692 [Mycolicibacterium fallax]
VSGFPARGELWWSELPEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLPSEVLLEPETDPVPRRSAVNLDSVESIATG
MLTHRLGRLADDRMRAISVALGVATGCSG

Download         Length: 330 bp

>T36309 NZ_AP022603:c3986021-3985692 [Mycolicibacterium fallax]
GTGAGCGGGTTCCCGGCACGCGGTGAGCTGTGGTGGAGCGAGCTGCCGGAGATCGGCCGGCGTCCGGTCGTGGTGCTGTC
CCGAGATGCCGCAATTCCGCGCCTGCGCCGCGCGCTGGTAGCGCCCTGCACAACCACCATCCGTGGATTACCCAGCGAAG
TGCTGCTGGAACCGGAAACCGATCCGGTACCGCGGCGATCGGCGGTCAATCTCGATTCGGTGGAGAGCATCGCCACCGGC
ATGCTGACCCACCGGCTGGGGCGTTTGGCCGACGACCGGATGCGCGCCATCAGCGTCGCGTTGGGCGTCGCGACGGGCTG
CTCCGGGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8224.00 Da        Isoelectric Point: 4.2943

>AT36309 WP_085092496.1 NZ_AP022603:c3986254-3986018 [Mycolicibacterium fallax]
MARTRLSTTVDAGLLDAARQRRPGGTDAALIDAALTALLAAHRAGEIDDAYRAYDDQPLDQPDDWGDLASWRAAAGAS

Download         Length: 237 bp

>AT36309 NZ_AP022603:c3986254-3986018 [Mycolicibacterium fallax]
ATGGCTCGCACACGCCTTTCCACCACCGTCGACGCCGGCCTGCTCGACGCCGCACGTCAACGGCGGCCCGGAGGGACCGA
CGCAGCACTCATCGACGCTGCCCTGACCGCACTGCTCGCCGCGCACCGTGCCGGTGAGATTGACGACGCCTACCGCGCCT
ACGACGATCAGCCGCTCGATCAACCCGACGACTGGGGCGATCTGGCGTCGTGGCGCGCGGCCGCCGGCGCATCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References