Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3867365..3867915 Replicon chromosome
Accession NZ_AP022603
Organism Mycolicibacterium fallax strain JCM 6405

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N10_RS18590 Protein ID WP_085092665.1
Coordinates 3867365..3867694 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N10_RS18595 Protein ID WP_085092666.1
Coordinates 3867691..3867915 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N10_RS18560 3862844..3863575 + 732 WP_085092660.1 lytic murein transglycosylase -
G6N10_RS18565 3863731..3865011 + 1281 WP_085092661.1 phosphopyruvate hydratase -
G6N10_RS18570 3865032..3865808 + 777 WP_085092662.1 septum formation initiator family protein -
G6N10_RS18575 3865801..3866310 + 510 WP_085092663.1 DUF501 domain-containing protein -
G6N10_RS18580 3866307..3867260 + 954 WP_085092664.1 Ppx/GppA family phosphatase -
G6N10_RS18590 3867365..3867694 - 330 WP_085092665.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N10_RS18595 3867691..3867915 - 225 WP_085092666.1 antitoxin MazE family protein Antitoxin
G6N10_RS18600 3867970..3868425 - 456 WP_085092667.1 Lrp/AsnC family transcriptional regulator -
G6N10_RS18605 3868509..3869144 + 636 WP_109750375.1 LysE family transporter -
G6N10_RS18610 3869171..3870187 + 1017 WP_085092668.1 patatin-like phospholipase family protein -
G6N10_RS18615 3870189..3871040 - 852 WP_085092669.1 patatin-like phospholipase family protein -
G6N10_RS18620 3871154..3872146 - 993 WP_085092670.1 esterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin MazE-like

(7-69)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11662.50 Da        Isoelectric Point: 10.0087

>T36307 WP_085092665.1 NZ_AP022603:c3867694-3867365 [Mycolicibacterium fallax]
VIRGEIWTASARQGYAGKPRPVVIVQDDRFDATDSITFCPFTSVAAAIPLLRIPVSPNAANGLSAPSSVMVDKITTAHKS
KLDRRIGAVSPSEMREIERALLVFLGLTG

Download         Length: 330 bp

>T36307 NZ_AP022603:c3867694-3867365 [Mycolicibacterium fallax]
GTGATCCGCGGCGAGATCTGGACCGCGTCCGCCCGGCAGGGCTATGCGGGCAAACCACGACCGGTCGTCATCGTCCAGGA
CGACCGATTCGACGCCACCGACTCAATCACCTTCTGCCCCTTCACCTCTGTCGCCGCTGCGATCCCCCTGCTGCGCATCC
CGGTGTCACCGAACGCCGCCAACGGACTCAGCGCGCCCAGCAGCGTCATGGTGGACAAAATCACCACGGCCCACAAGTCC
AAGCTCGACCGTCGTATCGGCGCGGTGTCCCCCAGTGAGATGCGGGAGATCGAGCGCGCGCTGCTGGTATTCCTCGGGCT
CACCGGCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8349.05 Da        Isoelectric Point: 4.5739

>AT36307 WP_085092666.1 NZ_AP022603:c3867915-3867691 [Mycolicibacterium fallax]
MASPDTNKRVADHRARLRGQGLRPLQIWVPDTRSAEFAAEAHRQSALAAIADRESGDQDWVDDVSEFNDPDFDR

Download         Length: 225 bp

>AT36307 NZ_AP022603:c3867915-3867691 [Mycolicibacterium fallax]
ATGGCCAGCCCAGACACCAACAAGCGCGTCGCCGACCACCGCGCCCGGCTTCGCGGCCAGGGATTGCGCCCGCTGCAGAT
CTGGGTGCCCGACACCCGCTCGGCCGAGTTCGCCGCCGAGGCCCACCGCCAGTCCGCACTCGCCGCGATCGCCGACCGCG
AATCCGGCGATCAGGACTGGGTGGACGACGTGTCCGAGTTCAACGACCCCGACTTCGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References