Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2596257..2596882 Replicon chromosome
Accession NZ_AP022603
Organism Mycolicibacterium fallax strain JCM 6405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N10_RS12395 Protein ID WP_163742408.1
Coordinates 2596502..2596882 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N10_RS12390 Protein ID WP_163742406.1
Coordinates 2596257..2596505 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N10_RS12375 2591747..2593090 - 1344 WP_085097228.1 sodium:proton exchanger -
G6N10_RS12380 2593413..2594159 - 747 WP_163742399.1 hypothetical protein -
G6N10_RS12385 2594152..2596011 - 1860 WP_163742403.1 N-6 DNA methylase -
G6N10_RS12390 2596257..2596505 + 249 WP_163742406.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N10_RS12395 2596502..2596882 + 381 WP_163742408.1 PIN domain-containing protein Toxin
G6N10_RS12400 2596887..2599253 - 2367 WP_163742411.1 hypothetical protein -
G6N10_RS12405 2599262..2599474 - 213 WP_133055044.1 hypothetical protein -
G6N10_RS12410 2600055..2601872 - 1818 WP_085092434.1 phosphoenolpyruvate carboxykinase (GTP) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(20-111)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13169.11 Da        Isoelectric Point: 5.5922

>T36306 WP_163742408.1 NZ_AP022603:2596502-2596882 [Mycolicibacterium fallax]
VRAILDTSVVIAGGVDPLDGDLAISAVTLAELHFGVLVARTGAVRAERLRRLLALQRGFDALPIDEAVAASYGQIAAAVV
DVGRQPRARSMDLLIAATAHAHSAALYTRNAGDFRGLDDLVDVITV

Download         Length: 381 bp

>T36306 NZ_AP022603:2596502-2596882 [Mycolicibacterium fallax]
GTGAGGGCGATCTTGGACACCAGCGTGGTGATCGCCGGGGGCGTCGACCCCCTCGATGGAGACCTCGCGATCAGTGCCGT
CACGCTCGCCGAGCTGCATTTCGGAGTTCTCGTCGCTAGGACTGGCGCAGTGCGCGCCGAAAGATTGCGGCGACTCCTCG
CCCTCCAGCGCGGATTCGATGCGCTGCCAATCGACGAGGCTGTGGCGGCCAGCTACGGCCAGATCGCGGCAGCAGTTGTC
GACGTCGGCCGTCAACCCCGCGCCAGGTCGATGGACTTACTCATCGCGGCGACCGCCCACGCGCACTCAGCAGCGCTCTA
CACGCGCAACGCCGGCGACTTTCGCGGACTTGACGACCTGGTCGACGTCATCACCGTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9160.22 Da        Isoelectric Point: 4.7962

>AT36306 WP_163742406.1 NZ_AP022603:2596257-2596505 [Mycolicibacterium fallax]
MQSVGLRELRQNASELVRRVEGGEEIAVTVAGRPGARLVPAKPRIWRQWSDVSELFTGPADPDWAADRDEIAHDIRDPWA
GQ

Download         Length: 249 bp

>AT36306 NZ_AP022603:2596257-2596505 [Mycolicibacterium fallax]
ATGCAATCCGTTGGCTTGCGTGAGCTACGCCAGAACGCCTCTGAGCTGGTGCGCCGGGTGGAAGGCGGCGAGGAGATCGC
CGTCACAGTGGCTGGCAGACCCGGCGCGAGATTGGTACCAGCCAAACCGAGAATCTGGCGACAGTGGTCCGACGTGTCCG
AGCTGTTCACTGGACCCGCCGATCCCGATTGGGCCGCCGACCGCGACGAGATCGCCCACGACATTCGCGACCCCTGGGCC
GGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References