Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1177456..1178145 Replicon chromosome
Accession NZ_AP022603
Organism Mycolicibacterium fallax strain JCM 6405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N10_RS05595 Protein ID WP_085093954.1
Coordinates 1177732..1178145 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N10_RS05590 Protein ID WP_085093956.1
Coordinates 1177456..1177728 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N10_RS05570 1172973..1174814 - 1842 WP_109750436.1 apolipoprotein N-acyltransferase -
G6N10_RS05575 1174807..1176414 - 1608 WP_085093962.1 amidohydrolase family protein -
G6N10_RS05580 1176425..1176952 - 528 WP_085093960.1 FxsA family protein -
G6N10_RS05585 1177002..1177382 - 381 WP_085093958.1 PPOX class F420-dependent oxidoreductase -
G6N10_RS05590 1177456..1177728 + 273 WP_085093956.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N10_RS05595 1177732..1178145 + 414 WP_085093954.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N10_RS05600 1178257..1180305 - 2049 Protein_1105 cobaltochelatase subunit CobN -
G6N10_RS05605 1180450..1182003 - 1554 Protein_1106 cobaltochelatase subunit CobN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14585.74 Da        Isoelectric Point: 5.1847

>T36305 WP_085093954.1 NZ_AP022603:1177732-1178145 [Mycolicibacterium fallax]
MIYLDTSALVKLIRLESESTALADWLDARTESRWITSTLTEIELPRAIRAIAPEGLASVPGVLARLDRFEIDDVVRATAA
AYSDPTLRSLDAIHLATAQIATAAAPLIAFVSYDRRLGDAAAAAGLVVAAPTAGKRR

Download         Length: 414 bp

>T36305 NZ_AP022603:1177732-1178145 [Mycolicibacterium fallax]
ATGATCTACCTGGACACCTCGGCCCTGGTGAAACTCATTCGCCTCGAATCCGAGTCCACCGCACTCGCCGACTGGCTCGA
CGCCCGGACCGAGTCCCGGTGGATCACCTCGACCCTGACCGAGATCGAACTGCCCCGGGCGATCCGCGCCATCGCCCCCG
AGGGCCTGGCGTCGGTGCCCGGCGTGCTGGCCCGGCTCGATCGCTTCGAGATCGACGACGTCGTCCGCGCGACCGCGGCC
GCATATTCGGACCCGACGCTCCGTTCGCTGGATGCGATACACCTGGCGACCGCCCAGATCGCCACCGCGGCGGCCCCGTT
GATCGCATTTGTCAGCTACGACCGCCGGCTCGGCGACGCCGCTGCGGCGGCCGGCCTGGTGGTCGCTGCGCCGACAGCGG
GCAAACGCCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9607.87 Da        Isoelectric Point: 8.7376

>AT36305 WP_085093956.1 NZ_AP022603:1177456-1177728 [Mycolicibacterium fallax]
VGEVSIRTLNQETSKVLARVKSGEEITLTERGVVVARITPATASPLAALISAERVRPASRTGAAPRPTIPAHDGVDSADV
LSRMRDDERY

Download         Length: 273 bp

>AT36305 NZ_AP022603:1177456-1177728 [Mycolicibacterium fallax]
GTGGGTGAAGTATCAATCCGGACGCTCAACCAGGAGACCTCCAAGGTGCTCGCCCGCGTCAAAAGCGGCGAGGAGATCAC
CCTCACCGAACGCGGCGTGGTCGTCGCGCGGATCACCCCGGCCACAGCCAGCCCGCTGGCCGCCCTGATCAGCGCGGAAA
GGGTCCGGCCGGCCAGCCGAACCGGCGCGGCCCCGCGACCCACCATCCCGGCGCACGACGGTGTCGACTCCGCGGACGTG
CTGAGCCGGATGCGCGACGACGAGCGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References