Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-yefM/MazF-YefM
Location 534411..535051 Replicon chromosome
Accession NZ_AP022603
Organism Mycolicibacterium fallax strain JCM 6405

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N10_RS02585 Protein ID WP_085094172.1
Coordinates 534411..534755 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag G6N10_RS02590 Protein ID WP_085094170.1
Coordinates 534794..535051 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N10_RS02570 529756..531018 + 1263 WP_085094178.1 restriction endonuclease subunit S -
G6N10_RS02575 531022..534123 + 3102 WP_085094176.1 type I restriction endonuclease subunit R -
G6N10_RS02580 534169..534417 + 249 WP_085094174.1 ribbon-helix-helix protein, CopG family -
G6N10_RS02585 534411..534755 + 345 WP_085094172.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N10_RS02590 534794..535051 + 258 WP_085094170.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N10_RS02595 535057..535317 + 261 WP_085094168.1 Txe/YoeB family addiction module toxin -
G6N10_RS02600 535412..536248 + 837 WP_085094166.1 acyl-CoA thioesterase II -
G6N10_RS02605 536245..536823 + 579 WP_085094164.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
G6N10_RS02610 536917..537672 + 756 WP_085094162.1 YebC/PmpR family DNA-binding transcriptional regulator -
G6N10_RS02615 537747..538598 + 852 WP_133055102.1 CHAP domain-containing protein -
G6N10_RS02620 538694..539251 + 558 WP_085094471.1 crossover junction endodeoxyribonuclease RuvC -
G6N10_RS02625 539248..539844 + 597 WP_085094159.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12105.89 Da        Isoelectric Point: 6.9776

>T36303 WP_085094172.1 NZ_AP022603:534411-534755 [Mycolicibacterium fallax]
VVIQRGGVCWVGVGELRGSAPAKRRPAVVVQSDRYNSSRISTMVVLPITSNTDLARHPGNVFLPALSSGLPKDSVVNVSQ
PMTVDRVDLDDTGVELPGSLMDAIDAGVRRVLDL

Download         Length: 345 bp

>T36303 NZ_AP022603:534411-534755 [Mycolicibacterium fallax]
GTGGTGATCCAGCGCGGAGGCGTGTGCTGGGTCGGCGTCGGCGAACTCAGGGGCAGCGCCCCCGCCAAGCGGCGACCGGC
CGTCGTCGTGCAATCCGACCGGTACAACTCGTCGAGAATCTCGACGATGGTCGTTCTGCCGATCACCTCGAACACGGACC
TTGCTCGGCACCCGGGCAACGTGTTCCTCCCGGCGCTGTCGTCCGGGTTGCCGAAGGACTCGGTCGTCAACGTCTCGCAG
CCGATGACCGTCGACCGCGTTGACCTCGATGACACGGGTGTGGAGCTGCCGGGCAGCCTGATGGACGCAATCGATGCGGG
TGTTCGGCGGGTGCTGGACCTGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9468.63 Da        Isoelectric Point: 4.4169

>AT36303 WP_085094170.1 NZ_AP022603:534794-535051 [Mycolicibacterium fallax]
MKTMSYTESRARYAEVLDSVVDDREEVVITRAGHEPVVIVSLADFESLRETAYLMRSPANARRLLDAMERLEGGGGTEHG
LLDVD

Download         Length: 258 bp

>AT36303 NZ_AP022603:534794-535051 [Mycolicibacterium fallax]
ATGAAGACCATGAGCTACACCGAATCGCGGGCCCGCTACGCGGAGGTCCTCGACAGCGTGGTGGACGATCGCGAAGAGGT
GGTCATCACCCGCGCCGGTCACGAGCCGGTGGTGATCGTTTCGCTCGCGGACTTCGAGTCGTTGCGCGAGACGGCCTACC
TGATGCGCTCGCCGGCCAACGCCCGTCGGCTGCTCGACGCCATGGAACGCCTGGAGGGTGGTGGCGGGACCGAGCACGGC
CTGCTCGACGTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References